AI Article Synopsis
- A real-world study in Sweden examined how missed basal insulin injections affect adults with type 1 diabetes (T1D) using data from continuous glucose monitors and smart insulin pens.
- Of the 32 participants, there was a 22% probability of missing at least one basal dose over a 14-day period, with missed doses linked to higher blood sugar levels and lower time spent in the target glucose range.
- The study highlights the difficulty of adhering to insulin injections and shows that even one missed injection per week can lead to significant negative impacts on glycemic control.
Article Abstract
Background: Adherence to basal insulin injections and the effects of missed basal insulin injections in adults with type 1 diabetes (T1D) were investigated using data from continuous glucose monitoring (CGM) and smart insulin pen devices in a real-world study.
Methods: This was a post hoc analysis of a prospective, real-world study conducted in Sweden. Adults with T1D who were using CGM received a smart insulin pen device (NovoPen 6) for insulin injections. Missed basal insulin doses (≥40 hours between doses) were evaluated over 14-day periods, and the probability of missing basal insulin doses was estimated. Associations between missed basal insulin doses and glycemic outcomes were also explored.
Results: Thirty-two patients with 4410 acceptable CGM days (315 14-day periods) were included. The number of missed basal insulin doses ranged from 0 to 4 over 315 14-day periods. The estimated probability of missing at least one basal insulin dose over any given 14-day period was 22% (95% confidence interval: 10%-40%). Missed basal insulin doses were significantly associated with higher mean glycemic levels, higher glucose management indicator, and lower time in range (70-180 mg/dL [3.9-10.0 mmol/L]). Similar results were observed when adjusted for missed bolus insulin doses; age and sex had no statistically significant effect on any glycemic parameter.
Conclusions: This is the first study, based on accurate real-world injection data, to demonstrate the challenge of adherence to basal insulin injections in patients with T1D, and document that just one missed basal injection per week can result in clinically significant changes in glycemic control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10899845 | PMC |
| http://dx.doi.org/10.1177/19322968221104142 | DOI Listing |
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