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http://dx.doi.org/10.3802/jgo.2022.33.e63 | DOI Listing |
ACS Omega
July 2024
Department of Civil, Construction and Environmental Engineering, Iowa State University, Ames, Iowa 50011, United States.
A critical prelude to any community odor assessment should be the prioritization of specific chemical odorants that are most responsible for targeted downwind odors. Unfortunately, and historically, this is a step that has often been bypassed or overlooked. However, correct understanding of the specific impactful volatile organic compounds (VOCs) can inform the follow-on sampling, analytical, and remediation strategies that are most appropriate and efficient, based upon the chemistry behind the issue.
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July 2024
The International Clinical Epidemiology Network (INCLEN) Trust International, F-1/5, 2Nd Floor, Okhla Industrial Area Phase - 1, New Delhi, Delhi, 110019, India.
Despite progress in reducing the infant mortality in India, the neonatal mortality decline has been slower, necessitating concerted efforts to achieve Sustainable Development Goal-3. A promising strategy aiming to prevent neonatal sepsis in high-risk, vulnerable, low birth weight neonates through an innovative intervention includes probiotic supplementation. This article communicates the decision by the ProSPoNS trial investigators to establish a Central Endpoint Adjudication Committee (CEAC) as an addendum to the protocol published in Trials in 2021 for the purpose of clarifying the primary outcome.
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March 2024
UCSF Center for Tuberculosis, University of California, San Francisco, San Francisco, CA, USA.
Background: Randomized trials for the treatment of tuberculosis (TB) rely on a composite primary outcome to capture unfavorable treatment responses. However, variability between trials in the outcome definition and estimation methods complicates across-trial comparisons and hinders the advancement of treatment guidelines. The International Council for Harmonization (ICH) provides international regulatory standards for clinical trials.
View Article and Find Full Text PDFBackground: Randomized trials for the treatment of tuberculosis (TB) rely on a composite primary outcome to capture unfavorable treatment responses. However, variability between trials in the outcome definition and estimation methods complicates across-trial comparisons and hinders the advancement of treatment guidelines. The International Council for Harmonization (ICH) provides international regulatory standards for clinical trials.
View Article and Find Full Text PDFActa Haematol
May 2024
Department of Medicine, Hematology and Oncology, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Background: Based on the new data from the primary analysis of the OPTIC (Optimizing Ponatinib Treatment in CP-CML) trial on dose optimization of ponatinib in patients with chronic phase (CP)-CML, the German consensus paper on ponatinib published in 2020 (Saussele S et al., Acta Haematol. 2020) has been updated in this addendum.
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