AI Article Synopsis
- Colorectal cancer ranks as the third most prevalent cancer globally, and recent interest in glucosamine and chondroitin highlights their potential benefits in cancer prevention alongside their established use for osteoarthritis.
- A systematic review analyzed studies from databases like PubMed and found a supportive link between glucosamine and chondroitin and reduced colorectal cancer incidence, suggesting their anti-inflammatory properties may play a role.
- The effectiveness of these supplements varies based on factors such as dosage, frequency of use, individual weight, and concurrent use of non-steroidal anti-inflammatory drugs, prompting the need for more rigorous clinical trials to confirm findings across diverse populations.
Article Abstract
Currently, colorectal cancer is the third most common cancer in the world. Recently, glucosamine and chondroitin have gained popularity for their beneficial effects on cancer. They have already been recognized for their therapeutic role in osteoarthritis. This systematic review aims to analyze the relationship between the combined consumption of glucosamine and chondroitin and the prevention of colorectal cancer. Three databases: PubMed, Google Scholar, and Science Direct, were searched to collect relevant articles. After screening full-text articles, seven studies were included in the systematic review. The review found a supportive association between glucosamine and chondroitin and the decreased incidence of colorectal cancer. Through an anti-inflammatory effect on the cell signaling pathway, the supplementation caused a reduction in colorectal cancer occurrence. The dose, frequency of usage of the supplement, and weight of individuals, along with the use of non-steroidal anti-inflammatory drugs, also affected the efficacy. To further assess this relationship, it is necessary to conduct double-blind, randomized controls trials for the supplements in cancer prevention and further explore their safety and efficacy with different ethnicities, drugs, doses, and weight individuals.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236665 | PMC |
| http://dx.doi.org/10.7759/cureus.25401 | DOI Listing |
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