The effect of acrolein on the formation of the 2-amino-1-methyl-6-phenylimidazo[4,5-]pyridine (PhIP) was investigated in a chemical model. Acrolein was found to increase PhIP formation at each tested addition level. 0-0.2 mmol of acrolein increased PhIP formation dose-dependently, while high levels of acrolein (>0.2 mmol) did not further increase PhIP formation. Mechanistic study showed that acrolein addition decreased the residue of phenylalanine and creatinine, but increased the content of some key intermediates. Further analysis indicated that acrolein can react with phenylalanine, creatinine, and PhIP to form adducts. These results suggested that acrolein was able to contribute to PhIP formation as a consequence of its comprehensive ability to facilitate Strecker degradation of phenylalanine and react with phenylalanine, creatinine, and PhIP. In addition, oxidation of the tilapia fish increased the PhIP formation in the roasted fish patties, further supporting the potential contribution role of lipid oxidation products to the formation of PhIP.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237630 | PMC |
| http://dx.doi.org/10.1016/j.fochx.2022.100315 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Short-Term Exposure to 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Induces Colonic Energy Metabolism Disorders in Rats.
J Agric Food Chem
November 2024
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is one of the most abundant heterocyclic aromatic amines generated in thermally processed meat products, and the toxicities of its short-term exposure in the intestines remain unclear. This study aimed to elucidate the short-term PhIP toxicity in colons through administering PhIP orally to rats for 4 weeks. The results indicated that short-term PhIP exposure induced colonic oxidative stress, a significant decrease of serum triglyceride, and a disrupted colonic gene expression pattern associated with mitochondrial electron transport chain and energy metabolism.
View Article and Find Full Text PDFComparing effects of tangerine-peel () age and concentration on deep-fried rabbit meat: Impact on heterocyclic aromatic amines, amino acids, and flavor compound formation.
Food Chem X
December 2024
Culinary College, Sichuan Tourism University, Chengdu 610100, China.
Many nutritional experts recommend rabbit meat as a high-protein source. However, the high temperatures used to prepare deep-fried rabbit meat (DFRM) typically produce numerous heterocyclic aromatic amines (HAAs), a class of substances with carcinogenic risks. In this study, we chromatographically evaluate changes in the volatile compounds, amino acids, and HAAs in DFRM while employing tangerine peel (TP) as an additive.
View Article and Find Full Text PDFNovel Insights: A Novel PHIP Variant in a Family with Severe Early-Onset Obesity.
Horm Res Paediatr
October 2024
Folkhälsan Research Center, Genetics Research Program, Helsinki, Finland.
Introduction: Severe childhood obesity can be caused by pathogenic variants in several genes involved in monogenic and syndromic obesity. Recently, heterozygous variants in pleckstrin homology domain interacting protein (PHIP) have been identified in patients with obesity as part of Chung-Jansen syndrome.
Case Presentation: The index patient is a 5-year-old boy with severe obesity since 1 year of age, developmental delay, facial dysmorphism, and behavior problems.
Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson-Forssman-Lehmann intellectual disability syndrome.
PLoS Genet
October 2024
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Börjeson-Forssman-Lehmann syndrome (BFLS) is an X-linked intellectual disability and endocrine disorder caused by pathogenic variants of plant homeodomain finger gene 6 (PHF6). An understanding of the role of PHF6 in vivo in the development of the mammalian nervous system is required to advance our knowledge of how PHF6 mutations cause BFLS. Here, we show that PHF6 protein levels are greatly reduced in cells derived from a subset of patients with BFLS.
View Article and Find Full Text PDFPreparation and characteristics of soy protein isolate - Sea buckthorn flavone emulsion and their effects of on quality and heterocyclic amines of roasted mutton granules.
Int J Biol Macromol
November 2024
School of Food Science and Engineering, Ningxia University, Yinchuan, Ningxia 750021, China. Electronic address:
Article Synopsis
- A soy protein isolate-sea buckthorn flavonoid emulsion was created to assess its impact on roasted lamb quality and the formation of harmful compounds called heterocyclic amines (HAAs).
- The emulsion demonstrated physical stability and uniform dispersion, while enhancing lamb texture by making it less chewy and hard, and reducing browning.
- Results indicated significant antioxidant effects, improving meat quality and greatly reducing the levels of HAAs and their precursors, with reductions ranging from about 44% to over 96%.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!