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The Psychosocial Burden of Pediatric Food Allergy in the United States: A Population-Based Survey.
J Allergy Clin Immunol Pract
December 2024
Center for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Feinberg School of Medicine, Northwestern University; Advanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL.
Background: Food allergy (FA) affects approximately one in 12 US children, with prevalence increasing. Aside from considerable health care utilization, accumulating research suggests heightened psychosocial burden among this population.
Objective: To characterize FA-related psychosocial burden among a large, nationally representative pediatric sample, and its correlates, including sociodemographic characteristics, comorbid conditions, allergy severity, allergic symptoms, number and type of allergens, and healthcare utilization.
Pharmacological interventions for patients with chronic primary musculoskeletal pain: disparity between synthesized evidence and real-world clinical practice.
Pain Rep
February 2025
Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Article Synopsis
- Chronic primary musculoskeletal pain (CPMP) significantly impacts public health, with many clinical trials focusing on pharmacological treatments that may not reflect actual clinical situations.
- This study compared a clinical sample of 103 CPMP patients from healthcare records to a larger randomized controlled trial (RCT) sample of 8,665 participants, analyzing demographic data and medications used.
- Findings revealed significant differences in medication distribution between the two groups, highlighting a gap between research and real-world treatment, emphasizing the need for further studies addressing the role of psychiatric comorbidities in CPMP management.
Author Correction: Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression.
Nat Neurosci
January 2025
Pamela Sklar Division of Psychiatric Genomics, Department of Psychiatry or Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Combined Dupilumab and Allergen-Specific Immunotherapy in Severe Refractory Atopic Dermatitis.
Allergy Asthma Immunol Res
November 2024
Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Combining allergen immunotherapy with biologics like dupilumab shows potential in treating severe atopic dermatitis (AD), which hasn't been extensively researched compared to conditions like asthma and allergic rhinitis.
- A study conducted at Severance Hospital in Korea evaluated the efficacy and safety of this combination therapy in 48 patients with severe AD, assessing treatment outcomes over 144 weeks based on established clinical scores and biomarker levels.
- Results indicated significant improvements in AD severity, decreased IgE levels, increased allergen-specific IgG4, and only mild side effects, suggesting this combined approach could be a beneficial option for patients who don't respond to standard treatments.
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