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Anterior ischemic optic neuropathy in patients treated with semaglutide: report of four cases with a possible association.
BMC Ophthalmol
March 2025
Department of Ophthalmology, Copenhagen University Hospital Rigshospitalet, Valdemar Hansens vej, 13, 2600, Glostrup, Denmark.
Background: Semaglutide, a glucagon-like peptide-1 receptor agonist, is increasingly used worldwide for its cardiometabolic benefits. However, it has recently been associated with nonarteritic anterior ischemic optic neuropathy (NAION). This report presents four clinical cases and explores a possible association.
View Article and Find Full Text PDFSarcoidosis presenting as a suspected metastasis around the optic disc.
BMJ Case Rep
March 2025
Ophthalmology, Te Whatu Ora Health New Zealand, Wellington, New Zealand
We present a case of systemic sarcoidosis presenting with mild blurred vision, limitation of left eye movements and choroidal infiltration around the left optic disc. Symptoms and signs of inflammation were absent, and secondary malignancy was suspected. After a prolonged series of investigations revealed multiple asymptomatic inflammatory lesions, subsequent lymph node biopsy revealed non-caseating granulomas.
View Article and Find Full Text PDFUnilateral choroidal detachment in an elderly patient with Vogt-Koyanagi-Harada disease: a case report and literature review.
Front Immunol
March 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Purpose: To report an uncommon case of Vogt-Koyanagi-Harada (VKH) disease in an elderly patient with unilateral choroidal detachment and describe its multimodal imaging features and prognosis.
Method: Case report and literature review of clinical features in VKH with choroidal detachment.
Results: A 76-year-old woman presented with bilateral blurred vision and headache 6 months prior to visiting our hospital.
Novel compound heterozygous variants in cause a like Dysplastic Optic Disc with macular abnormalities without coexistent microphthalmia or cataract.
Ophthalmic Genet
March 2025
Senior Consultant, Clinical Scientist and International Faculty, Pediatric Ophthalmology and Ocular Genetics, CMER (Shenzhen) Dennis Lam Hospital, Shenzhen, China.
Background: Congenital optic disc dysplasia with coexistent macular abnormalities is seen in Morning-glory disc anomaly, optic disc pit, -related disc coloboma, and in the -related Papillo-renal syndrome. We report novel compound heterozygous variants in causing optic disc dysplasia and macular abnormality without coexisting cataract or microphthalmia for the first time in Chinese ethnicity and also describe the macular OCT findings.
Materials And Methods: A 4 year-8 months-old female child presented with poor vision, photophobia, and nystagmus noticed 4 months after her birth was diagnosed elsewhere to have isolated cone dystrophy.
The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke.
Transl Vis Sci Technol
March 2025
Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Purpose: We aimed to analyze retinal neurovascular unit (RNVU) alterations and function via optical coherence tomography angiography (OCTA) and full-field electroretinography (ERG) in patients with ischemic stroke (IS).
Methods: OCTA was used to measure RNVU changes in 229 participants (101 with IS and 128 healthy controls). The RETeval device was used to record full-field electroretinograms (FERGs) in 40 participants (14 with IS and 26 healthy controls).
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