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Activating transcription factor-3 orchestrates the modulation of vascular anti-contractile activity and relaxation by governing the secretion of HDL-bound sphingosine-1-phosphate in perivascular adipose tissue.
Br J Pharmacol
January 2025
Department of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Background And Purpose: Perivascular adipose tissues (PVATs) play a critical role in modulating vascular homeostasis and protecting against cardiovascular dysfunction-mediated blood pressure dysregulation. We demonstrated that the activating transcription factor-3 (Atf3) gene in the PVAT is crucial for improving vascular wall tension abnormalities; however, its protective mechanism remains unclear. Herein, we aim to determine whether ATF3 regulates PVAT-derived relaxing factor (PVDRF) biosynthesis and if its secretion contributes to vasorelaxation.
View Article and Find Full Text PDFCombined chest wall perforator flap and synchronous fat grafting for partial breast reconstruction.
BMJ Case Rep
December 2024
Breast Surgery, Barts Health NHS Trust, London, UK.
Chest wall perforator flaps (CWPFs) have been a well-recognised surgical option for volume replacement following breast conservation surgery (BCS). However, the flap volume can sometimes be limited, which may adversely affect the aesthetic outcome or even disqualify the patient from having BCS. We report the first case of hybrid partial breast reconstruction using immediate autologous fat injection into CWPF.
View Article and Find Full Text PDFFEM simulation of breast deformation with semi-fluid representation.
Int J Comput Assist Radiol Surg
December 2024
Institute of Systems and Information Engineering, University of Tsukuba, 1-1-1 Tennodai, Tsukuba City, Ibaraki, 305-8573, Japan.
Purpose: In image-guided surgery for breast cancer, the representation of the breast deformation between planning and surgery plays a key role. The breast deforms significantly and behaves as a fluid with some constraints. Concretely, the deep fat layer in the breast deforms fluidly due to its incomplete fixation to the chest wall, while the anchoring structures by fascia avoid excessive deformation.
View Article and Find Full Text PDFComparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung Injury.
Stem Cells Int
October 2024
School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China.
Radiation-induced lung injury (RILI) is frequently observed in patients undergoing radiotherapy for thoracic malignancies, constituting a significant complication that hampers the effectiveness and utilization of tumor treatments. Ionizing radiation exerts both direct and indirect detrimental effects on cellular macromolecules, including DNA, RNA and proteins, but the impact of oxidized RNA in RILI remains inadequately explored. Mesenchymal stem cells (MSCs) can repair injured tissues, and the reparative potential and molecular mechanism of MSCs in treating RILI remains incompletely understood.
View Article and Find Full Text PDFCharacteristics of gene expression in epicardial adipose tissue and subcutaneous adipose tissue in patients at risk for heart failure undergoing coronary artery bypass grafting.
BMC Genomics
October 2024
Department of Cell and Molecular Biology, Science for Life Laboratory, Uppsala University, Box 596, Uppsala, S-751 24, Sweden.
Article Synopsis
- - The study investigates the differences in gene expression between epicardial adipose tissue (EAT) around the heart and subcutaneous adipose tissue (SAT) in patients undergoing heart surgery, revealing distinct gene clusters linked to heart failure (HF) characteristics.
- - Researchers identified 17 gene clusters in EAT, with seven showing significant correlations to heart failure measures, indicating a unique role that EAT may play in heart dysfunction, especially related to inflammation and tissue repair.
- - The findings emphasize the different impacts of EAT and SAT on heart health, suggesting that EAT could influence the progression of heart failure, which necessitates further studies to better understand these connections.
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