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http://dx.doi.org/10.1513/AnnalsATS.202111-1286CC | DOI Listing |
Pediatr Transplant
February 2025
School of Nursing, University of São Paulo, São Paulo, Brazil.
Background: When a family decides to donate the organs or tissues of their child with brain death, it is necessary to consider which organs or tissues will be donated. This phenomenon presents an ethical dilemma that is underexplored in the scientific literature, making it essential to examine this context to understand how refusals occur within donations.
Objective: To analyze the rates and trends of specific refusals for each organ and tissue from pediatric donors with brain death occurring between 2001 and 2020 in an Organ Procurement Organization in the State of São Paulo, Brazil.
Int J Sports Physiol Perform
January 2025
Human Performance Science Research Group, University of Edinburgh, Edinburgh, United Kingdom.
Background: Mental fatigue (MF) is a psychobiological state that could negatively impact physical and cognitive performance, although the extent of this impact remains controversial. While laboratory studies have provided valuable insights into the acute effects of MF, their ecological validity in real-world sport settings remains limited. Recent research indicates that MF can naturally arise during sport activities, leading to chronic effects on endurance and perceptual-cognitive skills.
View Article and Find Full Text PDFClin Oncol (R Coll Radiol)
December 2024
Proton Centre, The Christie NHS Foundation Trust, Manchester, UK.
Aims: Patient-centred radiotherapy refers to an approach where patients' needs and preferences are prioritised. Guidelines for this personalised approach are lacking. We present a multidisciplinary national consensus with the aim to provide recommendations for best practice in patient-centred radiotherapy for both clinical trials and routine practice.
View Article and Find Full Text PDFFront Cell Neurosci
January 2025
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Precision, or personalized, medicine aims to stratify patients based on variable pathogenic signatures to optimize the effectiveness of disease prevention and treatment. This approach is favorable in the context of brain disorders, which are often heterogeneous in their pathophysiological features, patterns of disease progression and treatment response, resulting in limited therapeutic standard-of-care. Here we highlight the transformative role that human induced pluripotent stem cell (hiPSC)-derived neural models are poised to play in advancing precision medicine for brain disorders, particularly emerging innovations that improve the relevance of hiPSC models to human physiology.
View Article and Find Full Text PDFSci Rep
January 2025
Faculty of Medicine, Department of Medical Education and Informatics, Karamanoğlu Mehmetbey University, Karaman, 70200, Türkiye.
With the importance of time and cost in today's world, it is essential to solve problems in the best way possible. Optimization is a process used to achieve this goal and is applied in several areas, one of which is route planning. Route optimization minimizes the use of resources such as fuel, distance, and time.
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