The paper uses text mining and semantic algorithms to tag innovative firms and offer an alternative perspective to classify industrial activities. Instead of referring to firms' standard industrial classification codes, we gather information from companies' websites and corporate purposes, extract keywords and generate tags concerning firms' activities, specializations, and competences. Evidence is interesting because allows us to understand 'what firms do' in a more penetrating and updated way than referring to standard industrial classification codes. Moreover, through matching firms' keywords, we can explore the degree of closeness between the firms under observation, a measure by which researchers can derive industrial proximity. The analysis can provide policymakers with a detailed and comprehensive picture of the innovative trajectories underlying the industrial structure in a geographic area.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9246165 | PMC |
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0270041 | PLOS |
Front Immunol
January 2025
Jiangsu Engineering Research Center of Biological Data Mining and Healthcare Transformation, Xuzhou Medical University, Xuzhou, China.
Introduction: Brucellosis is a widespread zoonotic disease that poses a considerable challenge to global public health. Existing diagnostic methods for this condition, such as serological assays and bacterial culture, encounter difficulties due to their limited specificity and high operational complexity. Therefore, there is an urgent need for the development of enhanced diagnostic approaches for brucellosis.
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Clinical Center for Biotherapy, Zhongshan Hospital, Fudan University, Shanghai 200433, China.
This study aimed to create a new recombinant virus by modifying the EV-A71 capsid protein, serving as a useful tool and model for studying human Enteroviruses. We developed a new screening method using EV-A71 pseudovirus particles to systematically identify suitable insertion sites and tag types in the VP1 capsid protein. The pseudovirus's infectivity and replication can be assessed by measuring postinfection luciferase signals.
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January 2025
Perron Institute for Neurological and Translational Science, Nedlands 6009, Australia.
Background/objectives: The role of α-synuclein (α-syn) pathology in Parkinson's disease (PD) is well established; however, effective therapies remain elusive. Two mechanisms central to PD neurodegeneration are the intracellular aggregation of misfolded α-syn and the uptake of α-syn aggregates into neurons. Cationic arginine-rich peptides (CARPs) are an emerging class of molecule with multiple neuroprotective mechanisms of action, including protein stabilisation.
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January 2025
College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Background: The 3-hydroxybutyrate dehydrogenase 1 (BDH1) mainly participates in the regulation of milk fat synthesis and ketone body synthesis in mammary epithelial cells. In our previous study, BDH1 was identified as a key candidate gene regulating lipid metabolism in mammary glands of dairy goats by RNA-seq. This study aimed to investigate the effect of BDH1 on lipid metabolism in mammary epithelial cells of dairy goats (GMECs).
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January 2025
State Key Laboratory of Cotton Bio-Breeding and Integrated Utilization, Institute of Cotton Research of Chinese Academy of Agricultural Sciences, Anyang, 455000, Henan, China.
Cotton is an important crop for fiber production, but the genetic basis underlying key agronomic traits, such as fiber quality and flowering days, remains complex. While machine learning (ML) has shown great potential in uncovering the genetic architecture of complex traits in other crops, its application in cotton has been limited. Here, we applied five machine learning models-AdaBoost, Gradient Boosting Regressor, LightGBM, Random Forest, and XGBoost-to identify loci associated with fiber quality and flowering days in cotton.
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