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Mortality prediction models for community-dwelling older adults: A systematic review.
Ageing Res Rev
November 2024
Department of General Practice, Department of General Practice, Amsterdam UMC, Meibergdreef 9 (Location AMC), Amsterdam 1105AZ, the Netherlands; Amsterdam Public Health research institute (Aging & Later Life), Meibergdreef 9 (Location AMC), Amsterdam 1105AZ, the Netherlands. Electronic address:
Article Synopsis
- - The increasing complexity of health issues among older adults makes it challenging for healthcare professionals to balance treatment benefits and risks, prompting a need for effective mortality prediction models.
- - This study systematically reviewed 22 studies with 38 unique mortality prediction models for community-dwelling seniors, finding that models based on frailty indices and machine learning demonstrated varying degrees of accuracy.
- - While some models performed well and showed potential for clinical use, there is a pressing need for standardized methodologies and further validation before widespread implementation.
Plasma cell-free RNA signatures of inflammatory syndromes in children.
Proc Natl Acad Sci U S A
September 2024
Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850.
Inflammatory syndromes, including those caused by infection, are a major cause of hospital admissions among children and are often misdiagnosed because of a lack of advanced molecular diagnostic tools. In this study, we explored the utility of circulating cell-free RNA (cfRNA) in plasma as an analyte for the differential diagnosis and characterization of pediatric inflammatory syndromes. We profiled cfRNA in 370 plasma samples from pediatric patients with a range of inflammatory conditions, including Kawasaki disease (KD), multisystem inflammatory syndrome in children (MIS-C), viral infections, and bacterial infections.
View Article and Find Full Text PDFAir pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways.
J Inflamm (Lond)
August 2023
Department of Clinical Immunology, Institute of Pediatrics, Jagiellonian University Medical College, Wielicka Street 265, 30-663, Krakow, Poland.
According to the World Health Organization (WHO), air pollution is one of the most serious threats for our planet. Despite a growing public awareness of the harmful effects of air pollution on human health, the specific influence of particulate matter (PM) on human immune cells remains poorly understood. In this study, we investigated the effect of PM on peripheral blood monocytes in vitro.
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