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Gulf war illness is a chronic multisymptom disorder that affects as many as many as 25-35% of the military personnel who were sent to the Persian Gulf war in 1991. The illness has many debilitating symptoms, including cognitive problems, gastrointestinal symptoms, and musculoskeletal pain. Those so afflicted have been sick for more than 30 years and, therefore, it has become imperative to understand the etiology and then produce treatments to ease the symptoms.
View Article and Find Full Text PDFAcute exposure to diisopropylfluorophosphate in mice results in persistent cognitive deficits and alterations in senescence markers in the brain.
Front Neurosci
November 2024
Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, United States.
Article Synopsis
- * Research on an OP nerve agent, diisopropylfluorophosphate (DFP), showed that even a single exposure could cause long-term impairments in cognitive functions, particularly spatial learning and working memory, while not impacting overall weight or noncognitive behaviors.
- * The study revealed that DFP exposure leads to changes in senescence markers and inflammatory cytokines in crucial brain areas, indicating that acute OP exposure can result in lasting cognitive deficits and potential biological aging effects.
A scoping review to determine if adverse human health effects are associated with use of organophosphates for mosquito control.
J Med Entomol
January 2025
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA.
Organophosphate insecticides are widely used for adult mosquito control. Although proven effective in reducing mosquito populations and limiting arbovirus transmission, public concern exists regarding potential human health effects associated with organophosphate exposure. The aim of this scoping review was to describe any reported human health conditions associated with organophosphates during their use for adult mosquito control in the United States and Canada.
View Article and Find Full Text PDFBurden of chemical poisoning and contributing factors in the case of the Amhara Region, Ethiopia.
BMC Public Health
September 2024
Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Article Synopsis
- This study assessed the impact of chemical poisoning in the Amhara region of Ethiopia, focusing on factors contributing to the issue and aiming to improve public health strategies.
- Conducted between June and November 2021, the research involved analyzing data from two hospitals, revealing 184 cases of poisoning and a 17% case fatality rate, predominantly affecting young females.
- Key findings included organophosphates being the main toxic agent, with significant associations found with factors like age, gender, type of exposure, and educational level, indicating the need for targeted interventions.
Biphasic response of human iPSC-derived neural network activity following exposure to a sarin-surrogate nerve agent.
Front Cell Neurosci
September 2024
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, United States.
Organophosphorus nerve agents (OPNA) are hazardous environmental exposures to the civilian population and have been historically weaponized as chemical warfare agents (CWA). OPNA exposure can lead to several neurological, sensory, and motor symptoms that can manifest into chronic neurological illnesses later in life. There is still a large need for technological advancement to better understand changes in brain function following OPNA exposure.
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