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Melatonin, modulation of hypothalamic activity, and reproduction.
Vitam Horm
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
Light is the most reliable environmental cue allowing animals to breed successfully when conditions are optimal. In seasonal breeders, photoperiod (length of daylight) information is sensed by the eyes and transmitted to the suprachiasmatic nucleus, the master clock region located in the hypothalamus. This structure has a 24-h firing rhythm involving a cycle of clock protein synthesis and degradation, and provides the timing to synchronize the synthesis and release of melatonin, the chemical signal that transduces the photoperiod information.
View Article and Find Full Text PDFThe inclusion and consideration of cultural differences and health inequalities in physical activity behaviour in the UK - the impact of guidelines and initiatives.
Prog Cardiovasc Dis
January 2025
Healthy Living for Pandemic Event Protection Network (HL-Pivot), UK; Research Centre for Physical Activity, Sport and Exercise Science, Coventry University, UK.
Despite widespread attempts from governments and leading health organisations worldwide to promote equity in healthy living medicine, the evidence suggests that attempts to curb worsening public health have been almost entirely ineffective. Despite significant advancements in knowledge, medicine, and technology, as well as the promotion of guidelines and the implementation of numerous global initiatives aimed at addressing health disparities and mitigating the progression of non-communicable diseases (NCDs) worldwide, substantial work remains to be undertaken particularly in addressing inequalities in physical activity. Achieving equitable access to health resources and parity in health outcomes remains a critical and unresolved challenge.
View Article and Find Full Text PDFA New target of ischemic ventricular arrhythmias-ITFG2.
Eur J Pharmacol
January 2025
Department of Basic Medicine, Institute of Respiratory Diseases Xiamen Medical College, Xiamen Medical College, Xiamen, Fujian 361023, P. R. China; State Key Laboratory of Frigid Zone Cardiovascular Diseases (SKLFZCD), Harbin Medical University, Harbin, Heilongjiang 150081, P. R. China. Electronic address:
ITFG2 is an intracellular protein known to modulate the immune response of T-cells. Our previous investigation revealed that ITFG2 specifically targets ATP5b to regulate ATP energy metabolism and maintain mitochondrial function, thereby protecting the heart from ischemic injury. However, the role of ITFG2 in ischemic ventricular arrhythmias and its underlying mechanisms have not been previously reported.
View Article and Find Full Text PDFDevelopment and applications of a machine learning model for an in-depth analysis of pentylenetetrazol-induced seizure-like behaviors in adult zebrafish.
Neuroscience
January 2025
Laboratory of Experimental Neuropsychobiology, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria, Santa Maria, RS, Brazil; Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, United States. Electronic address:
Epilepsy, a neurological disorder causing recurring seizures, is often studied in zebrafish by exposing animals to pentylenetetrazol (PTZ), which induces clonic- and tonic-like behaviors. While adult zebrafish seizure-like behaviors are well characterized, manual assessment remains challenging due to its time-consuming nature, potential for human error/bias, and the risk of overlooking subtle behaviors. Aiming to circumvent these issues, we developed a machine learning model for automating the analysis of subtle abnormal and seizure-like behaviors in PTZ-exposed adult zebrafish.
View Article and Find Full Text PDFRevealing the enhanced role of hydroxylamine and bimetals in the CuFeO/PMS/HA system towards effective degradation of organic contaminants.
J Hazard Mater
January 2025
Institute of Nanoscience and Nanotechnology, National Center for Scientific Research "Demokritos", Agia Paraskevi, Athens 15310, Greece. Electronic address:
In this study, a hydroxylamine (HA)-enhanced magnetic spinel catalyst CuFeO-activated peroxymonosulfate (PMS) system (CuFeO/PMS/HA) was constructed to degrade Sulfamethoxazole (SMX). Results from experiments and theoretical calculations indicated that active species generation mechanism involved the direct activation of PMS by HA, the redox cycles acceleration on the surface of CuFeO by HA, and the synergistic action of the low valence Fe and Cu species in CuFeO for PMS activation. The efficacy of other organic pollutants removal was further validated in bio-treated landfill leachate through removal performance and toxicity assessment.
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