Elevated Angiogenic Factor Levels After Transarterial Radioembolization for Colorectal Cancer Liver Metastases May Predict a Poor Prognosis.

Objectives: To analyze the change in circulating angiogenic factor levels after transarterial radioembolization (TARE) for colorectal cancer liver metastases (CRCLMs) and its prognostic significance.

Methods: Blood samples immediately before TARE and on 1 day, 1 week and 6 weeks after were collected for angiogenic factor analysis in 23 patients.

Results: Patients with elevated serum basic fibroblast growth factor and platelet-derived growth factor levels in the 1 week and vascular endothelial growth factor (VEGF) levels in the 6 week after TARE had significantly shorter median overall survival (OS) times.

Conclusion: Some early increases in serum angiogenic factor levels and in serum VEGF in the 6 week after TARE for CRCLMs are related to short OS and progression-free survival.