The bacterium sp. KMM 9044 from a sample of marine sediment collected in the northwestern part of the Sea of Japan produces highly chlorinated depsiheptapeptides streptocinnamides A () and B (), representatives of a new structural group of antibiotics. The structures of and were determined using nuclear magnetic resonance and mass spectrometry studies and confirmed by a series of chemical transformations. Streptocinnamide A potently inhibits sp. KMM 1467, sp. ATCC 21022, and MC2 155.
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| http://dx.doi.org/10.1021/acs.orglett.2c01714 | DOI Listing |
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