Musculoskeletal modelling is used widely for studying limb motion and its control, but simulation outcomes may depend heavily on the underlying muscle model used. The aim of this study was to investigate how intrinsic muscle properties affect reaching movements in a simple upper limb model. The simulations suggest that more realistic, higher-order activation dynamics requires longer prediction from a forward model and gives rise to a higher level of unplanned co-contraction than simple activation models. Consistent with prior work, muscle force-length-velocity properties stabilised and smoothed limb movements and furthermore helped promote accurate reaching performance with the high-order activation model.
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http://dx.doi.org/10.1080/10255842.2022.2089022 | DOI Listing |
Nat Commun
January 2025
Department of Hematopoietic Biology & Malignancy, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cells undergo tens of thousands of DNA-damaging events each day. Defects in repairing double-stranded breaks (DSBs) can lead to genomic instability, contributing to cancer, genetic disorders, immunological diseases, and developmental defects. Cohesin, a multi-subunit protein complex, plays a crucial role in both chromosome organization and DNA repair by creating architectural loops through chromatin extrusion.
View Article and Find Full Text PDFGeroscience
January 2025
Department of Physical Medicine and Rehabilitation, University of Missouri, Columbia, MO, USA.
Sarcopenia, the pathological age-related loss of muscle mass and strength, contributes to physical decline, frailty, and diminished healthspan. The impact of sarcopenia is expected to rise as the aging population grows, and treatments remain limited. Therefore, novel approaches for enhancing physical function and strength in older adults are desperately needed.
View Article and Find Full Text PDFHand Surg Rehabil
January 2025
Aspetar Orthopedic and Sports Medicine Hospital, Doha, Qatar; Qatar University, College of Medicine, Dept of Health and Clinical Sciences, Doha, Qatar; Karolinska Institutet, Department of Clinical Science and Education, Stockholm, Sweden.
An ulnar nerve (UN) palsy is devastating for hand function, resulting in an intrinsic minus position or claw hand with a loss of pinch grip. Distal nerve transfers facilitate faster reinnervation of hand intrinsic muscles in cases of proximal ulnar nerve lesions. The traditional anterior interosseous nerve (AIN) to UN motor transfer is commonly used, however, this still leads to long reinnervation times for the distal intrinsic muscles, important for the thumb to index pinch grip.
View Article and Find Full Text PDFHum Mov Sci
January 2025
Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Medical Device Innovation Center, National Cheng Kung University, Tainan, Taiwan; Department of Occupational Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address:
This study aimed to investigate the effect of hand muscle fatigue on finger control and force efficiency during piano performance, which is crucial for skilled piano playing among professional pianists engaged in prolonged periods of high-intensity practice or concert preparation. Thirty-one professional pianists were recruited as participants. This study was divided into three sequential experimental parts: pre-fatigue test, fatigue protocol, and post-fatigue test.
View Article and Find Full Text PDFJ Hand Surg Am
January 2025
Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, FL.
Purpose: The branching pattern of the deep motor branch of the ulnar nerve (DBUN) in the hand is complex. The anatomy of the motor branch innervating the fourth lumbrical (4L), where paralysis results in a claw hand deformity after ulnar nerve injury, is not well defined. This cadaver study focused on mapping and defining anatomical landmarks in relation to the motor branch to the 4L.
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