A number of peptides were isolated from pepsin hydrolyzate of cow k-casein by means of gel filtration on Sephadex G-50 and Biogel P-2, Dowex WX2 ion exchange chromatography in the pH step-wise gradient and dialysis using Sephadex G-10. The peptide material, after intravenous administration at a dose of 20 micrograms/kg of body mass, developed on electroencephalograms of various brain structures of starved rabbits the high amplitude, high frequent oscillations of electric potential corresponding to the effect of food satiation or to the action of cholecystokinin. Analysis of amino acid composition showed that the peptide fraction appears to be a fragment of para-k-casein moiety localized near one of Tyr residues containing in the protein molecule. Physiological effect of the peptide fraction was apparently related to regulation of satiation sense.
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