AI Article Synopsis
- The study focused on analyzing the -173 G/C polymorphism in the macrophage migration inhibitory factor (MIF) gene among children diagnosed with familial Mediterranean fever (FMF) and a control group.
- The research involved 98 children with FMF and 157 healthy children, using genotyping to assess the specific genetic variation at -173.
- Findings indicated a significant connection between the CC genotype of the MIF gene and an increased risk of FMF, suggesting that this polymorphism may contribute to heightened inflammation and immune response related to the condition.
Article Abstract
The aim of this study was to identify the genotypic analysis and allele frequencies of the -173 G/C polymorphism in the macrophage migration inhibitory factor ( ) gene in children diagnosed with familial Mediterranean fever (FMF). The study included 98 children who were diagnosed with FMF according to the Tel Hashomer criteria and one hundred and 57 healthy children as the control group. Genotyping was done for a polymorphism in a promoter region of the gene (G/C at position -173). The relationship of FMF prevalence and -173 G/C genotype of the gene was statistically significant. Individuals with the CC genotype seem to be predisposed to FMF. The C/C polymorphism at position -173 of the gene could be associated with excessive inflammation and immune response and can lead to susceptibility to FMF.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236749 | PMC |
| http://dx.doi.org/10.1055/s-0040-1719053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!