The widespread two-component system (TCS), QseBC, involves vital virulence regulators in and . Here we studied the function of QseBC in . A Δ mutant was constructed using a serovar 11 clinical strain SC1401 by natural transformation. Immunofluorescence was used to evaluate cellular adhesion, the levels of inflammation and apoptosis. The ability of Δ and Δ mutant strains to adhere to PAM and MLE-12 cells was significantly reduced. Additionally, by focusing on the clinical signs, H&E, and IFA for inflammation and apoptosis, we found that the Δ mutant weakened virulence in the murine models. Together, these findings suggest that QseBC plays an important role in the virulence of .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235811 | PMC |
| http://dx.doi.org/10.7717/peerj.13648 | DOI Listing |
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