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0.5T MRI as a competitor to CT for sinus imaging.
Sci Rep
December 2024
Department of Diagnostic Radiology, Dalhousie University, Halifax, Canada.
The goal of this study was to determine how radiologists' rating of image quality when using 0.5T Magnetic Resonance Imaging (MRI) compares to Computed Tomography (CT) for visualization of pathology and evaluation of specific anatomic regions within the paranasal sinuses. 42 patients with clinical CT scans opted to have a 0.
View Article and Find Full Text PDFOperation Polypharmacy: a pharmacist-led ambulatory care clinic design and evaluation for older patients.
Sci Rep
December 2024
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA.
The unintended consequences of polypharmacy pose significant risks to older adults. The complexities of managing numerous medications from multiple prescribers demand a comprehensive approach to mitigate harms. Pharmacist-led clinics have been shown to improve outcomes in patients with diabetes and hypertension.
View Article and Find Full Text PDFHeat stable and intrinsically sterile liquid protein formulations.
Nat Commun
December 2024
Department of Biomedical Engineering, Pennsylvania State University, University Park, PA, USA.
Over 80% of biologic drugs, and 90% of vaccines, require temperature-controlled conditions throughout the supply chain to minimize thermal inactivation and contamination. This cold chain is costly, requires stringent oversight, and is impractical in remote environments. Here, we report chemical dispersants that non-covalently solvate proteins within fluorous liquids to alter their thermodynamic equilibrium and reduce conformational flexibility.
View Article and Find Full Text PDFDiagnostic criteria for temporomandibular joint osteoarthritis using standardized uptake value in single-photon emission computed tomography-computed tomography.
Sci Rep
December 2024
Department of Oral and Maxillofacial Surgery, Yonsei University College of Dentistry, Gangnam Severance Hospital, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.
This study aimed to investigate the cutoff values of standardized uptake values (SUVs) and their accuracy using single-photon emission computed tomography-computed tomography (SPECT-CT) for temporomandibular joint (TMJ) osteoarthritis (OA) based on magnetic resonance imaging (MRI) and clinical examination. We included 106 joints of 53 patients with TMJ OA. SUVmax and SUVpeak of each TMJ was measured.
View Article and Find Full Text PDFHuman respiratory organoids sustained reproducible propagation of human rhinovirus C and elucidation of virus-host interaction.
Nat Commun
December 2024
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
The lack of a robust system to reproducibly propagate HRV-C, a family of viruses refractory to cultivation in standard cell lines, has substantially hindered our understanding of this common respiratory pathogen. We sought to develop an organoid-based system to reproducibly propagate HRV-C, and characterize virus-host interaction using respiratory organoids. We demonstrate that airway organoids sustain serial virus passage with the aid of CYT387-mediated immunosuppression, whereas nasal organoids that more closely simulate the upper airway achieve this without any intervention.
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