The paper develops theoretical estimates for the parameters that describe the classical theory of poroelasticity for a fluid-saturated porous medium, with a porous elastic skeleton that can exhibit imperfect grain contacts. The results for the poroelastic properties predicted from the modelling are compared with experimental results available in the literature.
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http://dx.doi.org/10.1038/s41598-022-14912-5 | DOI Listing |
PLoS Comput Biol
January 2025
Department of Mechanical Engineering, University of California Riverside, Riverside, California, United States of America.
Respiratory diseases represent a significant healthcare burden, as evidenced by the devastating impact of COVID-19. Biophysical models offer the possibility to anticipate system behavior and provide insights into physiological functions, advancements which are comparatively and notably nascent when it comes to pulmonary mechanics research. In this context, an Inverse Finite Element Analysis (IFEA) pipeline is developed to construct the first continuously ventilated three-dimensional structurally representative pulmonary model informed by both organ- and tissue-level breathing experiments from a cadaveric human lung.
View Article and Find Full Text PDFACS Omega
December 2024
Institute for Disposal Research, TU Clausthal, 38678 Clausthal-Zellerfeld, Germany.
Wellbore stability in extreme drilling environments remains a critical challenge. This study advances the understanding of these complexities through a comprehensive numerical modeling approach. By incorporating thermal, chemical, and hydraulic effects, four refined models were developed to simulate wellbore behavior under high pressures and temperatures.
View Article and Find Full Text PDFJ Mech Behav Biomed Mater
December 2024
Ifremer MASAE Microbiologie Aliment Santé Environnement, F-44000, Nantes, France.
In the field of tissue engineering, determining the mechanical properties of hydrogels is a key prerequisite to develop biomaterials mimicking the properties of the extracellular matrix. In mechanobiology, understanding the relationships between the mechanical properties and physiological state of cells is also essential. Time-dependent mechanical characterization of these soft materials is commonly achieved by atomic force microscopy (AFM) experiments in liquid environment.
View Article and Find Full Text PDFSoft Matter
November 2024
Department of Physics and Astronomy, Bucknell University, Lewisburg, PA 17837, USA.
Bioengineering (Basel)
September 2024
Adelaide Medical School, University of Adelaide, The Queen Elizabeth Hospital, Woodville South, Adelaide, SA 5011, Australia.
Changes in biomechanical properties such as elasticity modulus, viscosity, and poroelastic features are linked to the health status of biological tissues. Ultrasound elastography is a non-invasive imaging tool that quantitatively maps these biomechanical characteristics for diagnostic and treatment monitoring purposes. Mathematical models are essential in ultrasound elastography as they convert the raw data obtained from tissue displacement caused by ultrasound waves into the images observed by clinicians.
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