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Spatial separation of different drug substances in one microneedle array patch by combining inkjet printing and micromolding technology.
Int J Pharm
December 2024
Heinrich Heine University Duesseldorf, Faculty of Mathematics and Natural Sciences, Institute of Pharmaceutics and Biopharmaceutics, Universitätsstraße 1, Duesseldorf 40225, Germany. Electronic address:
Transdermal drug delivery using microneedle array patches has been investigated using a wide range of drug substances. Inkjet printing and micromolding are established methods for the production of microneedle array patches and both were used to combine lisinopril embedded in povidone and ibuprofen in Eudragit® RS / RL in a single patch. Dissolution studies, visual inspection, mechanical strength and insertion into an artificial skin membrane model were investigated.
View Article and Find Full Text PDFVestibular afferent neurons develop normally in the absence of quantal/glutamatergic input.
Front Neurol
November 2024
Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Article Synopsis
- - The vestibular nerve, crucial for balance, displays diversity among its neurons, influenced by low-voltage-gated potassium channels, particularly during early development when hair cell activity is significant.
- - Researchers studied mice without functional glutamate transmission from hair cells to see if their vestibular neurons still exhibited this biophysical diversity, using techniques like immunohistochemistry and patch-clamp electrophysiology.
- - The results indicated that even without glutamate input, the knockout mice maintained normal vestibular system development and function, showing no balance issues and preserving the diversity of vestibular neuron activity patterns, though some subtle changes were observed in the largest ganglion cells.
First Report of var. as a new host of in Sichuan, China.
Plant Dis
December 2024
Honghe University, College of Biological Sciences and Agriculture, Honghe Avenue, Mengzi City, Yunnan Province, Mengzi, China, 661199;
Article Synopsis
Genomics identifies koala populations at risk across eastern Australia.
Ecol Appl
November 2024
School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales, Australia.
Article Synopsis
Urticarial vasculitis.
Curr Opin Rheumatol
January 2025
Marmara University School of Medicine, Department of Dermatology, Istanbul, Türkiye.
Article Synopsis
- Urticarial vasculitis (UV) is a rare condition that can range from mild skin issues to serious systemic problems, and recent research focuses on its causes, diagnosis, and treatment options.
- New triggers for UV associated with SARS-CoV-2 and COVID-19 vaccines have been noted, along with a new clinical-dermoscopic method for diagnosis that reduces reliance on skin biopsies.
- Treatments such as antihistamines, corticosteroids, and rituximab show promise for success and long-lasting remission, while epidemiological studies show good survival rates but highlight certain severe health issues that can increase mortality.
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