AI Article Synopsis
- Vietnamese ginseng (Ngoc Linh ginseng) is a unique plant species native to Vietnam, from which five compounds were extracted and studied.
- Among these compounds, one new sesquiterpene lactone, panaxolide, was identified alongside four known compounds, using various advanced spectral techniques for structural analysis.
- In tests for cancer treatment potential, panaxolide demonstrated significant effectiveness, inhibiting the growth of HepG2 cancer cells with an IC value of 63.8 μM, more effectively than the other compounds tested.
Article Abstract
(Vietnamese ginseng, Ngoc Linh ginseng) is an endemic species of Vietnam. From the methanol extract of the leaves of , five compounds (-) were isolated, including one new sesquiterpene lactone such as panaxolide () and four known compounds. The structures of the compounds (-) were elucidated by spectral techniques such as 1 D NMR (H NMR, C NMR), 2 D NMR (COSY, HSQC, HMBC, NOESY) and mass spectrometry. The absolute configuration of was determined based on the Cotton effects in the CD spectrum. All of the five compounds were screened for their growth inhibitory activities against cancerous cells (HepG2) and normal cells (fibroblast) using the SRB assay. Panaxolide () showed the highest potential for the growth inhibition of cancerous cells HepG2 with the IC values of 63.8 μM.
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| http://dx.doi.org/10.1080/14786419.2022.2094374 | DOI Listing |
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