AI Article Synopsis
- This study investigated how placental damage from SARS-CoV-2 infection affects the transfer of antibodies from mother to fetus.
- Researchers analyzed the levels of specific anti-RBD IgG antibodies in maternal and cord blood comparing cases with and without placental injury.
- While the overall antibody levels didn't differ significantly, placental injury was linked to lower antibody transfer ratios from mother to baby.
Article Abstract
Background: We examined the relationship between placental histopathology and transplacental antibody transfer in pregnant patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods: Differences in plasma concentrations of anti-receptor biding domain (RBD) immunoglobulin (Ig)G antibodies in maternal and cord blood were analyzed according to presence of placental injury.
Results: Median anti-RBD IgG concentrations in cord blood with placental injury (n = 7) did not differ significantly from those without injury (n = 16) (median 2.7 [interquartile range {IQR}, 1.8-3.6] vs 2.7 [IQR, 2.4-2.9], P = 0.59). However, they were associated with lower transfer ratios (median 0.77 [IQR, 0.61-0.97] vs 0.97 [IQR, 0.80-1.01], P = 0.05).
Conclusions: SARS-CoV-2 placental injury may mediate reduced maternal-fetal antibody transfer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384443 | PMC |
| http://dx.doi.org/10.1093/infdis/jiac270 | DOI Listing |
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