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Immune thrombocytopenia possibly triggered by multiple tick bites.
Rev Inst Med Trop Sao Paulo
January 2025
Hospital Militar Central, Servicio de Infectología, Bogotá, Colombia.
Immune thrombocytopenia (ITP) is an autoimmune hematological condition characterized by a markedly isolated decrease in platelets without any apparent associated clinical conditions, resulting in bleeding and bruising of the skin, mucous membranes, and major organs. It is often triggered by preceding illness or several immune stimulants such as immunizations, infections, allergic reactions, among others. While uncommon, arthropod bites can trigger acute ITP.
View Article and Find Full Text PDFPlatelet mass index, systemic immune-inflammation index, and neutrophil-lymphocyte ratio as practical markers in childhood brucellosis.
Rev Paul Pediatr
January 2025
Afyonkarahisar Health Sciences University, Faculty of Medicine, Department of Child Health and Diseases, Afyonkarahisar, Turkey.
Objective: Brucellosis is a multisystem infectious disease and may cause an increase in acute phase reactants. This study aimed to examine the platelet mass index (PMI), the neutrophil-lymphocyte ratio (NLR), and systemic immune-inflammation index (SII) in children with brucellosis and to determine their roles in focal involvement.
Methods: This retrospective observational study included 69 patients with brucellosis and a control group of 69 healthy children.
Congenital toxoplasmosis in infants from chronically infected mothers: report of two cases.
Rev Paul Pediatr
January 2025
Universidade Federal de Goiás, Institute of Tropical Pathology and Public Health, Parasite-Host Relationship Studies Laboratory, Goiânia, GO, Brazil.
Objective: To describe two severe cases of congenital toxoplasmosis in infants born to chronically infected mothers who did not receive education or information on the prevention of gestational toxoplasmosis during prenatal care.
Case Description: The mothers had a previous serological diagnosis of toxoplasmosis conducted during prenatal care, with non-reactive (<10 IU/mL) IgM and reactive IgG (>10 IU/mL), and were considered "immune" to the infection. Both infants were born with sequelae of the congenital infection, including neurological and ocular alterations.
Protect or prevent? A practicable framework for the dilemmas of COVID-19 vaccine prioritization.
PLoS One
January 2025
Department of Electrical and Systems Engineering, University of Pennsylvania, Philadelphia, PA, United States of America.
Determining COVID-19 vaccination strategies presents many challenges in light of limited vaccination capacity and the heterogeneity of affected communities. Who should be prioritized for early vaccination when different groups manifest different levels of risks and contact rates? Answering such questions often becomes computationally intractable given that network size can exceed millions. We obtain a framework to compute the optimal vaccination strategy within seconds to minutes from among all strategies, including highly dynamic ones that adjust vaccine allocation as often as required, and even with modest computation resources.
View Article and Find Full Text PDFSecondary SARS-CoV-2 transmission by type of exposure setting among university students.
J Am Coll Health
January 2025
Department of Epidemiology, Columbia University Mailman School of Public Health, New York City, New York, USA.
We aimed to investigate the association between exposure settings and secondary SARS-CoV-2 transmission among university students. Students diagnosed with COVID-19 ( = 139) and randomly selected controls ( = 262) identified between April 4-December 5, 2021. This was a 1:2 case-control study.
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