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| http://dx.doi.org/10.1182/bloodadvances.2022008017 | DOI Listing |
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[Analysis of Gene Mutation and Clinical Characteristics Related to Myelodysplastic Syndrome].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu 233000, Anhui Province, China.
Objective: To explore the characteristics of gene mutation in patients with myelodysplastic syndrome (MDS) and its correlation with clinical features.
Methods: From January 2017 to December 2021, 172 patients with MDS in The First Affiliated Hospital of Bengbu Medical University were analyzed retrospectively. Fourteen high frequency genes related to MDS were detected, and the relationship between gene mutation and clinical characteristics of patients as well as revised International Prognostic Scoring System (IPSS-R) was analyzed.
Prognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience.
Medicine (Baltimore)
October 2024
Hematology Department, İzmir City Hospital, Bayrakli/İzmir, Turkey.
Article Synopsis
- * Recent studies utilizing next-generation sequencing (NGS) have identified numerous genetic abnormalities in patients with MDS, revealing mutations in 21 different genes that could correlate with disease characteristics and clinical outcomes.
- * Findings suggest that certain non-SF3B1 mutations are associated with worse clinical indicators, such as thrombocytopenia and decreased overall survival, indicating that NGS could play a crucial role in future prognostics for MDS, even in patients with normal cytogenetics.
Reclassification of Myelodysplastic Neoplasms According to the 2022 World Health Organization Classification and the 2022 International Consensus Classification Using Open-Source Data: Focus on and -mutated Myelodysplastic Neoplasms.
Ann Lab Med
January 2025
Department of Laboratory Medicine, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.
Background: In 2022, the WHO and International Consensus Classification (ICC) published diagnostic criteria for myelodysplastic neoplasms (MDSs). We examined the influence of the revised diagnostic criteria on classifying MDSs in a large population.
Methods: We retrieved an open-source pre-existing dataset from cBioPortal and included 2,454 patients with MDS in this study.
What is new in acute myeloid leukemia classification?
Blood Res
April 2024
Department of Laboratory Medicine, Chungbuk National University Hospital, 776, 1 Sunhwan-ro, Seowon-gu, Cheongju, Chungcheongbuk-do, 28644, Republic of Korea.
Recently, the International Consensus Classification (ICC) and the 5 edition of the World Health Organization classification (WHO2022) introduced diagnostically similar yet distinct approaches, which has resulted in practical confusion. This review compares these classification systems for acute myeloid leukemia (AML), building up on the revised 4th edition of WHO (WHO2016). Both classifications retain recurrent genetic abnormalities as a primary consideration.
View Article and Find Full Text PDFKinome expression profiling improves risk stratification and therapeutic targeting in myelodysplastic syndromes.
Blood Adv
May 2024
Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
The human kinome, which comprises >500 kinases, plays a critical role in regulating numerous essential cellular functions. Although the dysregulation of kinases has been observed in various human cancers, the characterization and clinical implications of kinase expressions in myelodysplastic syndromes (MDS) have not been systematically investigated. In this study, we evaluated the kinome expression profiles of 341 adult patients with primary MDS and identified 7 kinases (PTK7, KIT, MAST4, NTRK1, PAK6, CAMK1D, and PRKCZ) whose expression levels were highly predictive of compromised patient survival.
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