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http://dx.doi.org/10.1007/s40620-022-01367-0 | DOI Listing |
J Nephrol
November 2022
Department of Clinical and Experimental Medicine, Hematology Unit, University of Pisa, Pisa, Italy.
Blood Adv
February 2017
Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Clinical trials with carfilzomib have indicated a low but reproducible incidence of cardiovascular and renal toxicities. Among 60 consecutive myeloma patients treated with carfilzomib-based regimens who were thoroughly evaluated for cardiovascular risk factors, 12% (95% confidence interval, 3.8%-20%) experienced a reversible reduction of left ventricular ejection fraction (LVEF) by ≥20%, an objective measure of cardiac dysfunction.
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