Three new triterpenoid glycosides, 2,3,23,24-tetrahydroxyurs-12,19- dien-oic acid 28-O-- D -glucopyranoside (), 2,3,23,24-tetrahydroxyurs-12, 19(29) -dien-28-oic acid 28-O-- D -glucopyranoside (), and 2,3,23,24-tetrahydroxyurs-12, 18-dien-28-oic acid 28-O-- D -glucopyranoside () were isolated from (Michx.) Elliott. Their structures were elucidated by extensive spectroscopic methods. All the isolated compounds displayed moderate inhibitory activity against nitric oxide production in macrophages.
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http://dx.doi.org/10.1080/14786419.2022.2092863 | DOI Listing |
Molecules
December 2024
Centre des Sciences du Goût et de l'Alimentation, CNRS, INRAE, Institut Agro, Université de Bourgogne, 21000 Dijon, CEDEX, France.
Three new triterpene glycosides were isolated from x "Strawberry Fields" cultivar via aqueous-ethanolic extraction of the roots, including one derivative of sumaresinolic acid and two of echinocystic acid: 3--β-D-glucuronopyranosylsumaresinolic acid 28--β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester, 3--β-D-glucuronopyranosylechinocystic acid 28--β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester, and 3--α-L-arabinopyranosyl-(1→3)-β-D-glucuronopyranosylechinocystic acid 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl ester. As none of the isolated saponins were previously documented in the literature, their structural elucidation required extensive 1D and homo- and heteronuclear 2D NMR spectroscopy, as well as mass spectrometry analysis. All three glycosides were tested for their stimulatory activity of the sweet taste receptor TAS1R2/TAS1R3.
View Article and Find Full Text PDFBiomed Pharmacother
November 2024
School of Pharmaceutical Sciences, Jilin University, Changchun 130021, China. Electronic address:
Ulcerative colitis (UC), an incurable and recurrent inflammatory bowel disease, presents a significant threat to health and highlights the need for novel therapeutic strategies. Oleanolic acid 28-O-β-D-glucopyranoside (OAG) is a naturally occurring pentacyclic triterpenoid found in ginseng. In this study, we demonstrated that OAG exhibited remarkable anti-UC activity in LPS-induced Caco-2 cells and DSS-induced model mice.
View Article and Find Full Text PDFNat Prod Res
October 2024
Exact and Technological Sciences Campus, State University of Goiás, Anápolis, GO, Brazil.
Four novel triterpenoid saponins, 1,3,23-trihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester (), 1,3,23-trihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester (), 3---galloyl-1,23-dihydroxy-olean-12-en-28-oic acid 28---glycopyranoside ester () and 3---galloyl-1,23-dihydroxy-urs-12-en-28-oic acid 28---glycopyranoside ester () and two new pentacyclic triterpenoids, 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid () and 3-----coumaroyl-1-hydroxy-urs-12-en-28-oic acid (), together with six known compounds were isolated from the ethanolic extracts of leaves and stem bark. Their structures were established by HR-MS, 1D and 2D NMR and comparison with literature data. Additionally, the antimicrobial activity of the leaves and stem bark extracts and fractions was evaluated using the micro broth dilution technique.
View Article and Find Full Text PDFFront Plant Sci
September 2024
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
Introduction: The buds of Thunb. var. (Wats.
View Article and Find Full Text PDFIUCrdata
September 2024
Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.
The mol-ecular structure of CHO, (+)-diplodiatoxin, is described, whereby the absolute configuration of the structure of diplodiatoxin has been confirmed by single-crystal X-ray diffraction. Diplodiatoxin crystallizes in the chiral 422 space group with one mol-ecule in the asymmetric unit.
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