This column concerns the power of an RO1 grant from the federal government of the United States. To that end, a discussion of the philosophical viewpoints of power, the process of applying for federal grants, and a consideration of a more inclusive process will ensue.
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| http://dx.doi.org/10.1177/08943184221092441 | DOI Listing |
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High-resolution cryo-EM using a common LaB 120-keV electron microscope equipped with a sub-200-keV direct electron detector.
Sci Adv
January 2025
Ramaciotti Centre for Cryo-Electron Microscopy, Monash University, Clayton, VIC, Australia.
High-resolution cryo-electron microscopy (cryo-EM) requires costly 200- to 300-keV cryo-transmission electron microscopes (cryo-TEMs) with field emission gun (FEG) sources, stable columns, constant-powered lenses, autoloader, and direct electron detectors (DED). Recent advances in 100-keV imaging with the emergence of sub-200-keV optimized DED technology promises the development of more affordable cryo-TEMs. So far, 100-keV imaging has required microscopes with FEG sources.
View Article and Find Full Text PDFMapping emissions in Cyprus using TROPOMI observations: evaluation of the flux-divergence scheme using multiple parameter sets.
Environ Sci Pollut Res Int
January 2025
The Cyprus Institute, Climate and Atmosphere Research Center, 2121, Nicosia, Cyprus.
The production of nitrogen oxides (NO = NO + NO ) is substantial in urban areas and from fossil fuel-fired power plants, causing both local and regional pollution, with severe consequences for human health. To estimate their emissions and implement air quality policies, authorities often rely on reported emission inventories. The island of Cyprus is de facto divided into two different political entities, and as a result, such emissions inventories are not systematically available for the whole island.
View Article and Find Full Text PDFProbabilistic pressure-flow operating space for chromatographic resins using mechanistic modeling.
J Chromatogr A
December 2024
Biopharm Drug Substance Development, GSK, King of Prussia, PA 19406, US.
Article Synopsis
- Pressure drop in chromatography columns is influenced by column diameter and is challenging to predict without extensive data, but modern resin engineering has shifted focus from this issue due to larger beads.
- Recent advancements in small-bead resins for bioprocessing have rekindled interest in understanding pressure drop, prompting the development of a mechanistic model that uses force balances to make predictions based on minimal small-scale experiments.
- This model has been successfully tested and calibrated using different resins, allowing researchers to define safe operating ranges for pressure variables, enhancing the efficiency of resin screening before actual process development.
Three distinct gamma oscillatory networks within cortical columns in macaque monkeys' area V1.
Front Neural Circuits
December 2024
Cognitive Neurophysiology, Brain Research Institute, University of Bremen, Bremen, Germany.
Introduction: A fundamental property of the neocortex is its columnar organization in many species. Generally, neurons of the same column share stimulus preferences and have strong anatomical connections across layers. These features suggest that neurons within a column operate as one unified network.
View Article and Find Full Text PDFDevelopment and validation of a quantitative method for discriminating Korean and Japanese red seabream (Pagrus major) via UHPLC-QqQ-MS/MS.
Food Chem
December 2024
Department of Applied Chemistry ⋅ Food Science and Technology, Dong-eui University, Busan, Republic of Korea. Electronic address:
In this study, a robust and validated UHPLC-QqQ-MS/MS method was developed to quantify anserine and carnosine levels and their ratios to distinguish the geographical origin of red seabream (Pagrus major) from Japan and Korea. Comprehensive optimization of column types, mobile phase pH, organic solvent ratios, and internal standards identified the optimal conditions: an HILIC column at pH 5 with 75 % acetonitrile and PEH as the internal standard. The method exhibited excellent sensitivity, linearity, accuracy, and precision, establishing anserine as the most reliable biomarker for origin discrimination.
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