AI Article Synopsis
- - The study investigates how sex and age affect urine metabolomics by analyzing samples from 348 healthy children and 315 adults, ranging from 1 to 78 years, using advanced mass spectrometry techniques.
- - Findings show that sex differences in urine metabolites are more pronounced in adults than in children, with specific metabolic pathways differing across life stages; early life shows enrichment in certain pathways, while adolescence highlights androgen and estrogen metabolism.
- - The research provides valuable insights into urine metabolomic profiles throughout different ages, laying groundwork for future clinical studies focused on identifying disease biomarkers.
Article Abstract
Previous studies reported that sex and age could influence urine metabolomics, which should be considered in biomarker discovery. As a consequence, for the baseline of urine metabolomics characteristics, it becomes critical to avoid confounding effects in clinical cohort studies. In this study, we provided a comprehensive lifespan characterization of urine metabolomics in a cohort of 348 healthy children and 315 adults, aged 1 to 78 years, using liquid chromatography coupled with high resolution mass spectrometry. Our results suggest that sex-dependent urine metabolites are much greater in adults than in children. The pantothenate and CoA biosynthesis and alanine metabolism pathways were enriched in early life. Androgen and estrogen metabolism showed high activity during adolescence and youth stages. Pyrimidine metabolism was enriched in the geriatric stage. Based on the above analysis, metabolomic characteristics of each age stage were provided. This work could help us understand the baseline of urine metabolism characteristics and contribute to further studies of clinical disease biomarker discovery.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9233480 | PMC |
| http://dx.doi.org/10.7717/peerj.13545 | DOI Listing |
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