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Thiazides Attenuate Insulin Secretion Through Inhibition of Mitochondrial Carbonic Anhydrase 5b in β -Islet Cells in Mice.
J Am Soc Nephrol
July 2023
Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Significance Statement: Thiazide diuretics (thiazides) are among the most widely prescribed drugs worldwide, but their use is associated with glucose intolerance and new-onset diabetes mellitus. The molecular mechanisms remain elusive. Our study reveals that thiazides attenuate insulin secretion through inhibition of the mitochondrial carbonic anhydrase isoform 5b (CA5b) in pancreatic β cells.
View Article and Find Full Text PDFThiazide-Induced Pancreatitis.
Kans J Med
June 2022
Department of Internal Medicine, University of Kansas School of Medicine-Wichita, Wichita, KS.
Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics.
Expert Rev Cardiovasc Ther
June 2010
Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0486, USA.
Thiazide and thiazide-like diuretics are among the most commonly used antihypertensives and have been available for over 50 years. However, the mechanism by which these drugs chronically lower blood pressure is poorly understood. Possible mechanisms include direct endothelial- or vascular smooth muscle-mediated vasodilation and indirect compensation to acute decreases in cardiac output.
View Article and Find Full Text PDFAcute pancreatitis associated with angiotensin II receptor antagonists.
Ann Pharmacother
December 2002
Clinical Pharmacology and Toxicology, The Canberra Hospital, Woden, Australia.
Objective: To report a case of acute pancreatitis in a patient receiving a combination formulation of irbesartan and hydrochlorothiazide (HCTZ).
Case Summary: A 33-year-old white woman developed acute pancreatitis 10 days after starting irbesartan 300 mg and hydrochlorothiazide 12.5 mg for treatment of hypertension.
Do KCa channels and carbonic anhydrase play a role in thiazide-induced hyperglycaemia?
J Hum Hypertens
August 1995
Department of Clinical Pharmacology, Queen Elizabeth the Queen Mother Wing, St. Mary's Hospital Medical School, Imperial College of Science Technology and Medicine, London, UK.
Thiazide diuretics are widely used to treat hypertension, but their use is associated with impaired glucose tolerance. We propose that the diabetogenic action of thiazides may be due to their ability to open calcium-activated potassium (KCa) channels in pancreatic beta-cells.
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