AI Article Synopsis
- * Recent findings show that some venomous snails have evolved specialized insulins for hunting fish, illustrating how this hormone can be used in predation.
- * The review discusses the broader implications of repurposed insulins found in other venomous species and viruses, emphasizing their potential applications in medicine and insights into their unique biological roles.
Article Abstract
Insulin and its related peptides are found throughout the animal kingdom, in which they serve diverse functions. This includes regulation of glucose homeostasis, neuronal development and cognition. The surprising recent discovery that venomous snails evolved specialized insulins to capture fish demonstrated the nefarious use of this hormone in nature. Because of their streamlined role in predation, these repurposed insulins exhibit unique characteristics that have unraveled new aspects of the chemical ecology and structural biology of this important hormone. Recently, insulins were also reported in other venomous predators and pathogenic viruses, demonstrating the broader use of insulin by one organism to manipulate the physiology of another. In this Review, we provide an overview of the discovery and biomedical application of repurposed insulins and other hormones found in nature and highlight several unique insights gained from these unusual compounds.
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| http://dx.doi.org/10.1038/s41589-022-01068-6 | DOI Listing |
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