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| http://dx.doi.org/10.1016/j.ijsu.2022.106733 | DOI Listing |
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Reports of mpox are rising in Africa where the disease is endemic and in new countries where the disease has not been previously seen. The 2022 global outbreak of clade II mpox and an ongoing outbreak of the more lethal clade I mpox highlight the pandemic potential for monkeypox virus. Waning population immunity after the cessation of routine immunization for smallpox plays a key role in the changing epidemiologic patterns of mpox.
View Article and Find Full Text PDFBioluminescence Imaging to Study Recombinant Orthopoxvirus Infection in Animal Models.
Methods Mol Biol
December 2024
Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Bioluminescent images of viral replication in live animals (in vivo) reveal disease dynamics and effects of medical countermeasures over time. After selecting an appropriate orthopoxvirus animal model for the study, a recombinant virus with the firefly luciferase gene inserted in the genome is used to infect the animals. On the day of bioluminescent imaging, the substrate, D-luciferin, is prepared; animals are sedated and injected with the substrate and IVIS imager is utilized; various bioluminescent images are acquired; then animals recover and are able to continue in the study.
View Article and Find Full Text PDFPoxvirus Epidemiology.
Methods Mol Biol
December 2024
Poxvirus and Rabies Branch, Division of High Consequence Pathogens and Pathology, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA.
Article Synopsis
- Poxviruses, especially those in the orthopoxvirus genus, have caused significant health issues throughout history, with smallpox being a prominent example.
- Smallpox, caused by the Variola virus, was successfully eradicated in 1980, marking a milestone in public health and requiring extensive research on orthopoxviruses.
- The text explores both historical and current epidemiology of poxvirus infections, focusing on significant viruses like Monkeypox and Vaccinia.
Treatment efficacy of cidofovir and brincidofovir against clade II Monkeypox virus isolates.
Antiviral Res
November 2024
Special Pathogens Program, National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:
While historically confined to endemic areas, Monkeypox virus (MPXV) infection has increasingly garnered international attention due to sporadic outbreaks in non-endemic countries in the last two decades and its potential for human-to-human transmission. In 2022, a multi-country outbreak of mpox disease was declared by the World Health Organization (WHO) and nearly 100 000 mpox cases have been reported since the beginning of this pandemic. The clade II variant of the virus appears to be responsible for the vast majority of these infections.
View Article and Find Full Text PDFTecovirimat is the first-line antiviral treatment recommended for severe mpox or for persons with mpox who are at risk for severe disease; tecovirimat is available in the United States under an expanded access investigational new drug (IND) protocol. During the 2022-2023 mpox outbreak, local U.S.
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