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| http://dx.doi.org/10.1002/alr.23054 | DOI Listing |
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Clinical Manifestations.
Alzheimers Dement
December 2024
Concordia University, Montreal, QC, Canada.
Background: Sensory loss in hearing, vision, and olfaction are highly prevalent in older adults and are each associated with a higher risk of developing dementia. This study sought to identify the extent to which these sensory factors are associated with alterations in brain function and structure older adults with or at risk for dementia. We examined groups who range from relatively low risk (those with normal cognition and no cognitive complaints (NC)), to those with higher risk, namely individuals with subjective reports of cognitive decline (SCD) but normal cognition and those with mild cognitive impairment (MCI).
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Background: Olfactory impairment represents an early sensory marker of neurodegeneration, but little is known about how interindividual differences in the trajectories of olfactory change relate to dementia conversion. We aimed to characterize olfactory decline profiles during phases of normal cognition to assess their predictive value for dementia conversion.
Method: Olfactory trajectory profiles of dementia-free persons (SNAC-K; n = 1601; mean age = 70.
Clinical Manifestations.
Alzheimers Dement
December 2024
Consortium pour l'Identification précoce de la Maladie d'Alzheimer - Québec, Montréal/Québec/Sherbrooke, QC, Canada.
Background: Olfactory identification is impaired in the early stages of Alzheimer's disease (AD), including mild cognitive impairment (MCI). This early sensory impairment could result from several factors such as early cognitive or structural cerebral damages caused by the disease. It is however not clear which factors are contributing the most to the olfactory impairment in older people at risk of developing AD.
View Article and Find Full Text PDFImpact of posterior septectomy on olfaction in endoscopic endonasal transsphenoidal surgery.
PLoS One
January 2025
Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Background: Endoscopic endonasal transsphenoidal surgery is widely used to resect pituitary adenomas, yet its impact on olfactory function after resection of the posterosuperior nasal septum remains a concern. To optimize surgical techniques to preserve olfactory function, it is essential to understand the relationship between the extent of septal resection and olfactory outcomes.
Methods: This retrospective study analyzed 295 patients who underwent pituitary adenoma surgery.
Long-term Outcomes of PRP Injections for Post-viral Olfactory Loss: A Prospective Cohort Study.
Int Forum Allergy Rhinol
December 2024
Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.
Background: Platelet-rich plasma (PRP) injections have previously been shown to benefit coronavirus disease 2019 (COVID-19)-induced smell loss. It is unknown if that benefit is stable over time. The aim of this study was to assess outcomes at 1-year post-intervention.
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