Unlabelled: Glioblastoma (GB) is one of the most aggressive primary brain tumors. Analysis of molecular genetic factors affecting prognosis in patients with GB is an important direction of fundamental and clinical researches. There are literature data on the effect of gene mutations, methylation and status on overall survival in patients with GB.
Objective: To evaluate the incidence of gene promoter mutations in adults with primary GB and to analyze the effect of mutations on relapse-free and overall survival, as well as interaction of these mutations with gene methylation and mutations.
Material And Methods: The study included 56 patients (26 women and 30 men) with histologically verified GB in which genetic and molecular investigations were performed. There were patients with life duration >3 years (=15) and people with an extremely unfavorable course of disease (14 ones with primary multiple GB, 8 patients with GB metastases including extraaxial and 8 patients with life duration <8 months). gene sequencingwas performed in all the cases, status was known for 41 patients, status - for 23 patients.
Results: Overall survival significantly differed between patients with and without mutation (56 vs 17 months, >0.05). gene promoter mutation increased the effect of mutations on overall and relapse-free survival (=0.011). No and gene mutations worsened prognosis. There were no significant differences between status and development of primary multiple GBs, as well as extra- and intracranial metastases.
Conclusion: Thus, the combined status of and mutations was a factor of better prognosis and can be proposed in clinical practice.
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