Methylated as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia.

To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. The sensitivity/specificity of , and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83.9/93.1, 77.4/90.6 and 80.6/58.5%, respectively. The / test had a higher specificity than LBC (p < 0.001) and similar sensitivity to that observed for LBC (p > 0.05). / improved the positive predictive value of CIN3+ (64.7/60.0%) in low-grade LBC (negative predictive value: 91.7/88.7%). was superior to and LBC tests in detecting CIN3+ in hrHPV-infected women.