Objective: There is a paucity of data on antimicrobial resistance (AMR) in Malawi. Here we present a study of AMR of extended-spectrum β-lactamases-producing (ESBL-E) isolated from hospital and community settings in Blantyre, Malawi.
Design And Methods: A cross-sectional study was conducted between March and November 2020, involving 403 adult participants aged ≥18 years. Screening for ESBL-E was performed using CHROMagar ESBL medium. Production of ESBLs was confirmed by a combination disk test method. Antimicrobial susceptibility was tested using the agar disk diffusion method in accordance with the Clinical Laboratory Standards Institute's 2019 guidelines.
Results: The mean resistance rate of ESBL-E to antimicrobial agents tested was 49.2% (range from 1.4%-92%). The highest resistance rates were observed for trimethoprim-sulfamethoxazole (92%), amoxicillin and ceftriaxone (79%), doxycycline (75%) and gentamicin (72%). Carbapenems (meropenem and imipenem) were highly active against isolates. The overall rate of multi-drug resistant (MDR) ESBL-E was 47%. The highest MDR was found in (51%) and the least in spp. (40%).
Conclusions: We found a high resistance rate of ESBL-E isolates to antimicrobial agents; the majority were MDR. Surveillance systems are recommended to monitor AMR in Malawi.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216276 | PMC |
| http://dx.doi.org/10.1016/j.ijregi.2021.08.002 | DOI Listing |
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