AI Article Synopsis
- - Severe malaria (SM) significantly contributes to illness and death, especially among children in sub-Saharan Africa, but current diagnostic tests struggle to identify those at high risk of severe outcomes.
- - Research indicates that the body's immune responses and blood vessel activation play a key role in the severity of SM, suggesting that certain biological markers could help predict disease progression and risk of death.
- - This review highlights the potential of soluble urokinase-type plasminogen activator receptor (suPAR) as a promising early predictor for severe and fatal malaria, which could improve patient management and treatment strategies.
Article Abstract
Severe malaria (SM) is a leading cause of global morbidity and mortality, particularly in children in sub-Saharan Africa. However, existing malaria diagnostic tests do not reliably identify children at risk of severe and fatal outcomes. Dysregulated host immune and endothelial activation contributes to the pathogenesis of SM. Current research suggests that measuring markers of these pathways at presentation may have clinical utility as prognostic indicators of disease progression and risk of death. In this review, we focus on the available evidence implicating soluble urokinase-type plasminogen activator receptor (suPAR) as a novel and early predictor of severe and fatal malaria and discuss its potential utility for malaria triage and management.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226448 | PMC |
| http://dx.doi.org/10.3389/fimmu.2022.931321 | DOI Listing |
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