AI Article Synopsis
- Progesterone is crucial for implantation, and lower levels during the luteal phase are linked to reduced pregnancy chances, according to multiple studies.
- A systematic review analyzed data from 32 relevant studies to determine the relationship between luteal serum progesterone levels and outcomes like ongoing pregnancy, live birth rates, and miscarriage rates.
- Findings show that low progesterone levels significantly decrease ongoing pregnancy and live birth rates in cycles without a corpus luteum and increase the risk of miscarriage, suggesting the importance of monitoring these hormone levels for better individualized treatment.
Article Abstract
Unlabelled: Progesterone plays a key role in implantation. Several studies reported that lower luteal progesterone levels might be related to decreased chances of pregnancy. This systematic review was conducted using appropriate key words, on MEDLINE, EMBASE, and the Cochrane Library, from 1990 up to March 2021 to assess if luteal serum progesterone levels are associated with ongoing pregnancy (OP) and live birth (LB) rates (primary outcomes) and miscarriage rate (secondary outcome), according to the number of corpora lutea (CLs). Overall 2,632 non-duplicate records were identified, of which 32 relevant studies were available for quantitative analysis. In artificial cycles with no CL, OP and LB rates were significantly decreased when the luteal progesterone level falls below a certain threshold (risk ratio [RR] 0.72; 95% confidence interval [CI] 0.62-0.84 and 0.73; 95% CI 0.59-0.90, respectively), while the miscarriage rate was increased (RR 1.48; 95% CI 1.17-1.86). In stimulated cycles with several CLs, the mean luteal progesterone level in the no OP and no LB groups was significantly lower than in the OP and LB groups [difference in means 68.8 (95% CI 45.6-92.0) and 272.4 (95% CI 10.8-533.9), ng/ml, respectively]. Monitoring luteal serum progesterone levels could help in individualizing progesterone administration to enhance OP and LB rates, especially in cycles without corpus luteum.
Systematic Review Registration: https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=139019, identifier 139019.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229589 | PMC |
| http://dx.doi.org/10.3389/fendo.2022.892753 | DOI Listing |
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