A Case of Delayed Hepatic Injury Associated with Teriflunomide Use as Assessed for Causality Using the Updated RUCAM.

Case Reports Hepatol

Department of Internal Medicine, University of New Mexico Hospital, UNM School of Medicine MSC08 47201, University of New Mexico, Albuquerque, NM 87131, USA.

Published: June 2022

Teriflunomide is a pyrimidine synthesis inhibitor used in the treatment of multiple sclerosis that has in rare instances been associated with liver toxicity, though there are few documented cases. Here, we report a case of probable teriflunomide-induced liver injury as assessed for causality using the updated RUCAM. The liver injury occurred approximately nine months after teriflunomide initiation and improved with discontinuation of the drug and treatment with cholestyramine.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9217622PMC
http://dx.doi.org/10.1155/2022/6331923DOI Listing

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