AI Article Synopsis
- Osteoradionecrosis of the jaw (ORN) is a serious condition that can develop in head and neck cancer patients receiving radiotherapy, with conflicting opinions on whether pre-treatment tooth extractions increase ORN risk.
- A study analyzed 366 patients with oral or oropharyngeal cancer who received radiotherapy to assess risk factors for ORN, finding that certain dental conditions and post-treatment tooth extractions raised the risk.
- The results indicated that extracting infected teeth before radiotherapy could significantly lower the incidence of ORN, highlighting the importance of dental health management in cancer treatment.
Article Abstract
Background/purpose: Osteoradionecrosis of the jaw (ORN) often occurs in patients with head and neck cancer undergoing radiotherapy (RT). It has been recommended to extract the tooth before RT that may become source of infection, but in recent years, some investigators have reported that tooth extraction before RT increase the risk of developing ORN and therefore should be avoided. The purpose of the study is to evaluate the risk factors for ORN including tooth extraction before RT.
Materials And Methods: This was a retrospective study of 366 patients with oral or oropharyngeal cancer who underwent RT of 50 Gy or more at six university hospitals, with follow-up of at least six months post-RT. The relationship between each factor and ORN incidence was analyzed using the Cox proportional hazard model.
Results: Periapical lesions, more than 50% loss of alveolar bone, and tooth extraction after RT significantly correlated with ORN. Intensity-modulated RT showed a lower incidence than three-dimensional conformal RT, although not statistically different. Tooth extraction before RT significantly reduced ORN incidence, after adjusting the background factors using propensity score matching.
Conclusion: In patients with oral or oropharyngeal cancer who underwent RT, periapical lesions, more than 50% loss of alveolar bone, and tooth extraction after RT significantly increased the risk for ORN. Infected tooth extraction before RT significantly reduced the risk.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9201633 | PMC |
| http://dx.doi.org/10.1016/j.jds.2021.10.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The effect of commonly employed forensic DNA extraction protocols on ssDNA/dsDNA proportion and DNA integrity.
Forensic Sci Int Genet
December 2024
Estonian Forensic Science Institute, Tallinn, Estonia.
The utilisation of massively parallel sequencing (MPS) in forensic DNA analysis is on the rise, driven by the expansion of targeted MPS panels in the market and the introduction of forensic investigative genetic genealogy. The MPS library preparation process, integral to both whole-genome sequencing (WGS) and targeted MPS panel data generation, is largely based on converting double-stranded DNA (dsDNA) into sequencing libraries. In the current study, we examined the effect of seven routinely used forensic DNA extraction methods on the strandedness (single-stranded or double-stranded) and the fragment size of the DNA extracted from buccal swab, blood, bone and tooth samples.
View Article and Find Full Text PDFInsulin for oral bone tissue engineering: a review on innovations in targeted insulin-loaded nanocarrier scaffold.
J Drug Target
December 2024
Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM'S Narsee Monjee Institute of Management Studies, Shirpur-425405, Maharashtra, India.
The occurrence of oral bone tissue degeneration and bone defects by osteoporosis, tooth extraction, obesity, trauma, periodontitis, and congenital defects are major challenges for clinicians. Traditional bone regeneration methods, although exhibiting efficacy to a certain degree, often come with limitations such as donor site morbidity, limitation of special shape, inflammation, and resorption of the implanted bone. The treatment oriented with biomimetic bone materials has achieved significant attention recently.
View Article and Find Full Text PDFThe conflict between oral health and patient autonomy in dentistry: a scoping review.
BMC Med Ethics
December 2024
Institute of Behavioural Sciences, Semmelweis University, Budapest, Hungary.
Background: Respect for patient autonomy, the principle that patients are capable to make informed decisions about medical interventions, is fundamental in present-day medicine. However, if a patient's request is medically not indicated, the practitioner faces an ethical dilemma represented by the conflict of the principles of patient autonomy, beneficence, and maleficence. Adjacent to topics such as medical assistance in dying and healthy limb amputation, this ethical dilemma also manifests in the care of the maxillofacial region (the oral cavity and its surroundings), an area crucial to esthetic appearance, but also to everyday functions including mastication, speech, and facial expression, all of which are related to well-being.
View Article and Find Full Text PDFThe Surgical Dental Anxiety Scale (SDAS).
Br Dent J
December 2024
Bristol Dental School, University of Bristol, United Kingdom.
Dental anxiety is a prevalent issue in society and national surveys show it to be rising. As a result, strain on sedation services continues to grow. To accommodate this, there is a need to streamline services to ensure that patients who have a clinical need for sedation are able to receive it.
View Article and Find Full Text PDFNon-healing extraction socket: a diagnostic challenge for general dental practitioners.
Br Dent J
December 2024
UCL Eastman Dental Institute, University College London, United Kingdom.
Introduction In the UK, more than 18 million extractions are performed annually. Healing after extraction is often uneventful, but there are rare cases where weeks or months pass and an extraction socket does not heal.Aim The aim of this study is to provide a review of cases in which a non-healing extraction socket is attributed to a serious systemic disease or malignancy, or an adverse consequence of systemic therapy.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!