AI Article Synopsis
- pSEV (peak saccadic eye velocity) is a key measure linked to GABA receptor function and has been studied in relation to menstrual cycle mood disorders like PMDD.
- Despite its use in drug studies, there’s a lack of research on how pSEV responds to natural hormone fluctuations during the menstrual cycle.
- This pilot study found that pSEV is significantly lower during the luteal phase compared to the follicular phase, suggesting a potential link between menstrual hormones and GABA receptor activity.
Article Abstract
Peak saccadic eye velocity (pSEV) has been investigated in studies that characterise the pathophysiology of menstrual cycle related mood disorders, such as premenstrual dysphoric disorder (PMDD). pSEV is a stable and sensitive measure of gamma-aminobutyric acid A (GABA) receptor function. Dysregulation of the GABA pathway has been associated with the onset of PMDD. Despite a growing number of studies utilising pSEV as an outcome measure in interventional drug studies for menstrual cycle related mood disorders, there are no reported studies that have investigated whether pSEV is sensitive to hormone fluctuations across the natural menstrual cycle. To address this gap, this pilot study aimed to characterise pSEV in women across the menstrual cycle. Participants were monitored across two menstrual cycles and saccadic eye movements were measured in both luteal and follicular phases. Seven participants completed the full study and were included in the final analysis. Results revealed luteal phase pSEV was significantly less than follicular phase pSEV. This finding is novel and forms a stepping-stone for further understanding the associations between menstrual hormone profiles and GABA receptors.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9216255 | PMC |
| http://dx.doi.org/10.1016/j.cpnec.2020.100009 | DOI Listing |
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