AI Article Synopsis
- The study evaluated the use of 70mg/kg oral chloral hydrate for sedating children aged 1 day to 5 years undergoing MRI to determine its safety and effectiveness.
- The research involved 3132 outpatient patients over 20 years, analyzing variables like age, hemodynamic stability, and complication rates.
- Results indicated that chloral hydrate provides effective sedation with low incidences of complications such as respiratory issues, agitation, and nausea, making it a safe choice for short non-invasive procedures.
Article Abstract
Objective: To assess the mean time to hypnosis, hemodynamic stability, and incidence of complications associated with the administration of 70mg/kg oral chloral hydrate in children scheduled for magnetic resonance imaging (MRI).
Material And Methods: Prospective study conducted from January 2000 to January 2020 in which 3132 patients aged between one day and 5 years underwent MRI under anaesthesia in an outpatient setting. The study population was divided into 4 subgroups: A) aged between one and 30 days; B) aged between one month and one year; C) aged between one and 3 years, and D) aged between 3 and 5 years. Study variables were: sex, age, type of examination, mean imaging time, mean time to awakening, heart rate before and after MRI, SatO, and incidence of complications such as respiratory depression (SatO below 90%), agitation during the MRI or on awakening (intense crying lasting more than 2min), prolonged sedation measured on the Steward scale, and nausea and/or vomiting during the MRI, on awakening, or at home.
Results: No notable hemodynamic alterations were observed. The incidence of desaturation was .41%, awakening during the test was .16%, prolonged sedation was 1.08%, and agitated awakening was 1.46%. Nausea and vomiting at the end of the test had an incidence of .73%. The P value in all cases was <.05%.
Conclusions: Chloral hydrate at a dose of 70mg/kg continues to be suitable in sedation lasting no more than one hour for non-invasive procedures in children, and is associated with adequate haemodynamic stability with practically no side effects.
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| http://dx.doi.org/10.1016/j.redare.2021.03.017 | DOI Listing |
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- Chloral hydrate is a sedative used mainly in children for procedures like dental sedation and can be adapted for different patient needs due to a lack of commercially available age-appropriate forms.
- Researchers created a customizable oral liquid formulation of chloral hydrate using a suspending vehicle called PCCA SuspendIt, which is free from sugar, dyes, and gluten, to improve dosing accuracy for both pediatric and adult patients.
- The study aimed to develop and validate a stability-indicating assay using ultra-high-performance liquid chromatography (UPLC) to ensure the chemical stability of chloral hydrate at varying concentrations.
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