AI Article Synopsis
- A 43-year-old woman experienced symptoms like weakness, tingling, and difficulty swallowing 12 days after receiving the Pfizer COVID-19 vaccine.
- Medical tests revealed normal cerebrospinal fluid but decreased nerve conduction, leading to a diagnosis of immune-mediated polyneuropathy linked to the vaccine.
- Treatment with plasma exchange improved her condition, indicating a potential non-specific immune response as a contributing factor compared to other similar cases.
Article Abstract
A 43-year-old-woman developed paresthesia, weakness of limbs, dysphagia and deep sensory impairment 12 days after vaccination of Pfizer COVID-19 vaccine. Her deep tendon reflexes were absent and cerebrospinal fluid showed normal cell counts and protein level. Anti-ganglioside antibodies were negative, and F wave frequency was decreased in nerve conduction studies. We diagnosed her as immune mediated polyneuropathy caused by COVID-19 vaccine, and plasma exchange improved her symptoms. Compared with Guillain-Barré syndrome and polyneuropathy following COVID-19 infection and COVID-19 vaccination, deep sensory impairment was the most characteristic of this case. We supposed that non-antigen specific mechanism played an important role in the pathogenesis of this case.
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