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The impact of myocardial injury on outcomes in TAVI patients.
Clin Res Cardiol
December 2024
Department of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Petersgraben 4, CH-4031, Basel, Switzerland.
Article Synopsis
- The study investigates the impact of peri-procedural myocardial injury (PPMI) after transcatheter aortic valve implantation (TAVI) using the updated VARC-3 criteria compared to the previous VARC-2 criteria.
- High-sensitivity cardiac troponin T (hs-cTnT) levels were assessed pre- and post-procedure, with elevated baseline levels being significant predictors of all-cause mortality and major cardiac adverse events within one year post-TAVI.
- The findings indicate that VARC-3 criteria offered better prognostic insights regarding patient outcomes, with patients meeting VARC-3 criteria experiencing higher mortality rates than those meeting VARC-2 criteria.
Influence of physiological patterns of coronary disease on fractional flow reserve and instantaneous wave-free ratio changes in patients undergoing TAVI.
Int J Cardiol
February 2025
Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Article Synopsis
- This study examined how the physiological patterns of coronary artery disease (CAD) in patients with severe aortic stenosis (SAS) change before and after transcatheter aortic valve implantation (TAVI).* -
- It found that most patients had diffuse CAD, and vessels that showed a decrease in fractional flow reserve (FFR) post-TAVI had lower pre-TAVI measurements and exhibited significant gradients.* -
- Instantaneous wave-free ratio (iFR) changes were inconsistent, with both increases and decreases observed in vessels despite similar low pre-TAVI FFR and iFR values.*
Computational hemodynamic indices to identify Transcatheter Aortic Valve Implantation degeneration.
Comput Methods Programs Biomed
February 2025
Department of Perioperative Cardiology and Cardiovascular Imaging, Centro Cardiologico Monzino IRCSS, via Carlo Parea 4, Milan, 20138, Italy; Department of Biomedical, Surgical and Dental Sciences, Università degli studi di Milano, Via della Commenda 10, Milan, 20122, Italy.
Background And Objectives: Structural Valve Deterioration (SVD) is the main limiting factor to the long-term durability of the bioprosthetic valves used for Transcatheter Aortic Valve Implantation (TAVI), a minimally invasive technique for the treatment of severe aortic stenosis. The aim of this retrospective study is to perform patient-specific computational analyses of blood dynamics shortly after TAVI to identify hemodynamic indices that correlate with a premature onset of SVD which is detected at 5-10 years long-term follow-up exam after TAVI.
Methods: The study population comprises fourteen patients: seven cases with SVD at long-term follow-up were identified and seven cases without SVD were randomly extracted from the same cohort.
Predictive potential of pre-procedural cardiac and inflammatory biomarkers regarding mortality following transcatheter aortic valve implantation: A systematic review and meta-analysis.
Heart Lung
November 2024
Sina Hospital Department of Internal Medicine, Tehran, Iran. Electronic address:
Background: Aortic stenosis (AS) is a common heart valve disease, especially in aging populations. While surgical aortic valve replacement (SAVR) is the standard treatment, many patients are ineligible. Transcatheter aortic valve implantation (TAVI) offers an alternative, especially for high-risk patients, but is not without complications.
View Article and Find Full Text PDFComprehensive geriatric assessment, and related interventions, to improve outcomes for older patients undergoing transcatheter aortic valve implantation (TAVI): a systematic review.
Eur Geriatr Med
December 2024
Department of Ageing and Health, Guy's and St Thomas' NHS Foundation Trust, London, SE1 7EH, UK.
Article Synopsis
- TAVI is a procedure designed for patients with severe aortic stenosis, particularly those who are frail, but frailty can lead to worse outcomes after the procedure.
- This systematic review analyzed studies to evaluate the effectiveness of Comprehensive Geriatric Assessment (CGA) and interventions related to it in improving outcomes for older adults undergoing TAVI.
- The review found limited evidence on the effectiveness of CGA, highlighting a need for better-designed trials to understand its impact on post-TAVI outcomes for frail older adults.
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