Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.peptides.2022.170835 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of Peptide Ligation Strategies for the Synthesis of the Bivalent Acid-Sensing Ion Channel Inhibitor Hi1a.
Org Lett
June 2023
Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia.
Hi1a is a naturally occurring bivalent spider-venom peptide that is being investigated as a promising molecule for limiting ischemic damage in strokes, myocardial infarction, and organ transplantation. However, the challenges associated with the synthesis and production of the peptide in large quantities have slowed the progress in this area; hence, access to synthetic Hi1a is an essential milestone for the development of Hi1a as a pharmacological tool and potential therapeutic.
View Article and Find Full Text PDFCIPPS, an Australian Centre for Peptide and Protein Research, goes live!
Peptides
September 2022
Institute for Molecular Bioscience, Australian Research Council Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:
Total Synthesis of Glycosylated Human Interferon-γ.
Org Lett
September 2020
School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Interferon-γ (IFN-γ) is a glycoprotein that is responsible for orchestrating numerous critical immune induction and modulation processes and is used clinically for the treatment of a number of diseases. Herein, we describe the total chemical synthesis of homogeneously glycosylated variants of human IFN-γ using a tandem diselenide-selenoester ligation-deselenization strategy in the C- to N-terminal direction. The synthetic glycoproteins were successfully folded, and the structures and antiviral functions were assessed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!