AI Article Synopsis
- A novel compound called IPM714, derived from 1H-imidazole [4,5-f][1,10] phenanthroline, has shown potential as an effective treatment for colorectal cancer (CRC) by selectively inhibiting CRC cell growth.
- The research demonstrated that IPM714 had a half maximal inhibitory concentration (IC) of 1.74 μM and 2 μM against HCT116 and SW480 cells, respectively, and induces cell cycle arrest and apoptosis in these cancer cells.
- Analysis revealed that IPM714 likely targets the PI3K/AKT/mTOR signaling pathway, which plays a key role in regulating cell proliferation and survival, making it a promising candidate for CRC therapy.
Article Abstract
1H-imidazole [4,5-f][1,10] phenanthroline is a promising chemical structure for cancer treatment. Herein, we synthesized a novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative named IPM714 and found it exhibited selectively colorectal cancer (CRC) cells inhibitory activities, with half maximal inhibitory concentration (IC) of 1.74 μM and 2 μM in HCT116 cells and SW480 cells, respectively. The present study is intended to explore the cytotoxicity of IPM714 in cancer cells of various types and its anticancer mechanism in vitro. Cellular functional analyses indicated IPM714 can arrest HCT116 cell cycle in S phase and induce apoptosis in HCT116 and SW480 cells. Western blot and molecular docking showed that IPM714 may suppress PI3K/AKT/mTOR pathway to inhibit cell proliferation and regulate cell cycle as well as apoptosis. This study proved IPM714 to be a promising drug in CRC therapy.
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| http://dx.doi.org/10.1016/j.ejphar.2022.175120 | DOI Listing |
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