AI Article Synopsis
- The study examined neonatal Staphylococcus aureus (SA) sepsis cases at a neonatal intensive care unit in Western Australia from 2001 to 2020, focusing on incidence rates and risk factors.
- The incidence of SA sepsis was found to decrease over the two decades, from 0.13 to 0.07 per 1000 live births, and was associated with a longer duration of ventilatory support and poorer neurodevelopmental outcomes in affected infants.
- The findings highlight the need for awareness of endotracheal tube colonization and prolonged ventilation as potential sources of infection, while suggesting that interventions may be helping to reduce SA sepsis incidence.
Article Abstract
Objectives: The purpose of this study was to characterise neonatal Staphylococcus aureus (SA) sepsis in Western Australia (WA) between 2001 and 2020 at the sole tertiary neonatal intensive care unit (NICU), examine risk factors for sepsis in the cohort, and compare short- and long-term outcomes to control infants without any sepsis.
Methods: Retrospective cohort study at the Neonatal Directorate at King Edward Memorial Hospital (KEMH) and Perth Children's Hospital, using electronic databases and patient medical records.
Results: The overall incidence of SA sepsis was 0.10 per 1000 live births (62/614207). From 2001 to 2010 the incidence was 0.13/1000 live births, reducing to 0.07/1000 live births from 2011 to 2020. SA was most frequently isolated from endotracheal aspirates, and infants with SA sepsis had longer median duration of ventilatory support than those without any sepsis (31 days vs 18 days respectively, p < 0.001). In our cohort, SA sepsis was associated with worse neurodevelopmental outcomes compared to infants without any sepsis.
Conclusions: The incidence of neonatal SA sepsis has reduced over the last 20 years, suggesting potential effectiveness of the preventative interventions implemented. Endotracheal tube (ETT) colonisation and prolonged ventilation may be under-recognised as potential sources of SA infection. Our study suggests SA sepsis may negatively impact neurodevelopmental outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9616716 | PMC |
| http://dx.doi.org/10.1038/s41372-022-01440-3 | DOI Listing |
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