AI Article Synopsis
- - The COVID-19 pandemic has significantly impacted health care, highlighting different disease courses in patients, especially those with compromised immune systems, like pediatric heart transplant recipients.
- - Observations of four pediatric patients revealed varying severity of symptoms, with one being infected during surgery and others requiring hospitalization or outpatient care.
- - Treatment strategies involved reducing immunosuppression and using medications like remdesivir and steroids, with active viral replication lasting between 3 to 8 weeks after initial symptoms.
Article Abstract
The COVID-19 pandemic that has been ongoing since the beginning of 2020 has forced health care into a difficult struggle for wellness and the lives of patients. International data and our observations show that the course of the disease in these patients is different than in the general population. Symptoms depend on the immunosuppression and severity of viremia. The period of viral replication is much longer. Our observations include 4 pediatric patients post heart transplant who became infected with the coronavirus. One patient was infected in the hospital during perioperative period. Two others required hospitalization because of the severity of symptoms, and 1 was treated on an outpatient basis. The applied treatment included the reduction of immunosuppression, low-molecular-weight heparin, amantadine or remdesivir, steroids, and supplementation with zinc and vitamins C and D. Based on the antigenic tests performed, we determined the period of active replication to be 3 to 8 weeks from the onset of the first symptoms.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9221402 | PMC |
| http://dx.doi.org/10.1016/j.transproceed.2022.03.020 | DOI Listing |
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