MAVS Expression in Alveolar Macrophages Is Essential for Host Resistance against .

Our recent data demonstrate a critical role of the RIG-I-like receptor family in regulating antifungal immunity against in a murine model. However, the importance of this pathway in humans and the cell types that use this innate immune receptor family to detect remain unresolved. In this study, using patients who underwent hematopoietic stem cell transplantation, we demonstrate that a polymorphism in human present in the donor genome was associated with the incidence of invasive pulmonary aspergillosis. Moreover, in a separate cohort of confirmed invasive pulmonary aspergillosis patients, polymorphisms in the gene alter the inflammatory response, including IFN-responsive chemokines. Returning to our murine model, we now demonstrate that CD11c Siglec F alveolar macrophages require expression to maintain host resistance against Our data support the role of MAVS signaling in mediating antifungal immunity in both mice and humans at least in part through the role of MAVS-dependent signaling in alveolar macrophages.