Pocahemiketone A, a novel sesquiterpenoid possessing a unique spirocyclic skeleton with a hemiketal endoperoxide unit, was isolated from the essential oil of . Its structure was determined by spectroscopic methods and single-crystal X-ray diffraction analyses. Pocahemiketone A exhibits a significant neuroprotective effect against Aβ-induced damage in SH-SY5Y cells by inhibiting NLRP3 inflammasome-mediated pyroptosis and oxidative stress. These results indicate that pocahemiketone A has great potential for use in the treatment of Alzheimer's disease.
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